Wester Vincent L, Noppe Gerard, Savas Mesut, van den Akker Erica L T, de Rijke Yolanda B, van Rossum Elisabeth F C
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Psychoneuroendocrinology. 2017 Jun;80:1-6. doi: 10.1016/j.psyneuen.2017.02.024. Epub 2017 Feb 27.
Scalp hair is increasingly used to measure the long-term exposure to endogenous glucocorticoids hormones. Long-term cortisone (HairE) and cortisol (HairF) have been associated with obesity, metabolic syndrome, cardiovascular disease and psychopathology. However, little is known about the influence of the use of local corticosteroids and major stressful life events on hair glucocorticoids.
We determined HairE and HairF using liquid chromatography - tandem mass spectrometry in 295 adult participants of the population-based Lifelines cohort study (75% females, median age 42). We collected anthropometry and fasting metabolic laboratory values, questionnaires on hair characteristics, recent use of corticosteroids, and recent major stressful life events.
After adjustment for covariates, hair glucocorticoids increased with age, male sex, black or brown hair color, and frequency of sweating on the scalp, and decreased with higher hair washing frequency (P<0.05). HairE was decreased in participants who used systemic corticosteroids (5.4 vs. 8.5pg/mg hair, P=0.041), and in participants who only used local agents such as inhaled, topical and nasal corticosteroids (6.8 vs. 8.5pg/mg, P=0.005). Recent life events were positively associated with HairF after adjustment for age and sex (P=0.026), but this association lost significance after adjustment for hair related characteristics (P>0.05).
HairE can be a useful marker to detect mild adrenal suppression due to corticosteroid use in the general population, even when only inhaled, nasal or topical corticosteroids are used, which suggests that these commonly used agents induce systemic effects.
头皮毛发越来越多地被用于测量内源性糖皮质激素的长期暴露情况。长期可的松（毛发E）和皮质醇（毛发F）与肥胖、代谢综合征、心血管疾病及精神病理学有关。然而，关于局部使用皮质类固醇和重大生活应激事件对毛发糖皮质激素的影响，人们了解甚少。
在基于人群的生命线队列研究的295名成年参与者（75%为女性，中位年龄42岁）中，我们使用液相色谱 - 串联质谱法测定毛发E和毛发F。我们收集了人体测量数据和空腹代谢实验室值、关于毛发特征的问卷、近期皮质类固醇的使用情况以及近期重大生活应激事件。
在对协变量进行调整后，毛发糖皮质激素随年龄、男性性别、黑色或棕色头发颜色以及头皮出汗频率增加而升高，随洗发频率升高而降低（P<0.05）。使用全身性皮质类固醇的参与者毛发E降低（5.4 vs. 8.5pg/mg毛发，P = 0.041），仅使用吸入、局部和鼻用皮质类固醇等局部制剂的参与者毛发E也降低（6.8 vs. 8.5pg/mg，P = 0.005）。在对年龄和性别进行调整后，近期生活事件与毛发F呈正相关（P = 0.026），但在对毛发相关特征进行调整后，这种关联失去显著性（P>0.05）。
毛发E可作为检测普通人群中因使用皮质类固醇导致轻度肾上腺抑制的有用标志物，即使仅使用吸入、鼻用或局部皮质类固醇，这表明这些常用制剂会产生全身效应。
