Dopfer R, Ehninger G, Schmidt H, Waller H D, Niethammer D
Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Tübingen, Federal Republic of Germany.
Blut. 1987 Oct;55(4):199-204. doi: 10.1007/BF00320090.
In February 1986 we transplanted a 10-year-old girl with AML in second remission with the bone marrow of an unrelated donor. HLA-types were different for one A- and one B-antigen between patient and donor. Conditioning regimen consisted of 14 Gy total body irradiation with lung shielding, 8 X 3 g/m2 cytosin arabinoside and 90 mg/kg cyclophosphamide. GVHD-prophylaxis was performed with cyclosporin A, methotrexate and prednisolone. Only mild GVHD I of the skin could be observed after rapid engraftment. 100 days after transplantation the patient was in good clinical condition and GVHD-prophylaxis was discontinued without any reactivation of acute or chronic GVHD. Engraftment was documented by sex chromosome and blood group typing. 120 days after transplantation leukemic blasts were detected in the peripheral blood and the child died 130 days after BMT from relapse of the leukemia. Despite the negative outcome, this was the first successful bone marrow transplantation from a unrelated donor in Germany.
1986年2月，我们用一位无关供者的骨髓为一名处于第二次缓解期的10岁急性髓系白血病（AML）女孩进行了移植。患者与供者之间的HLA型别在一个A抗原和一个B抗原上不同。预处理方案包括14 Gy全身照射并屏蔽肺部、8次3 g/m²阿糖胞苷以及90 mg/kg环磷酰胺。采用环孢素A、甲氨蝶呤和泼尼松龙预防移植物抗宿主病（GVHD）。快速植入后仅观察到轻度皮肤I度GVHD。移植后100天，患者临床状况良好，停止GVHD预防，急性或慢性GVHD均未再次激活。通过性染色体和血型分型记录植入情况。移植后120天在外周血中检测到白血病原始细胞，该患儿在骨髓移植后130天死于白血病复发。尽管结果不佳，但这是德国首例成功的无关供者骨髓移植。
