Biomedical Engineering Group, University of Seville, Seville, Spain.
Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocio, Seville, Spain.
Clin Respir J. 2021 Mar;15(3):247-256. doi: 10.1111/crj.13300. Epub 2020 Nov 11.
The aim of this work is to present a review on the impact of genetics and altitude on lung function from classic and recent studies.
A systematic search has been carried out in different databases of scientific studies, using keywords related to lung volumes, spirometry, altitude and genetics.
The results of this work have been structured into three parts. First, the relationship between genes and lung function. Next, a review of the genetic predispositions related to respiratory adaptation of people who inhabit high-altitude regions for millennia. Finally, temporary effects and long-term acclimatisation on respiratory physiology at high altitude are presented.
The works focused on the influence of genetics and altitude on lung function are currently of interest in terms of studying the interactions between genetic, epigenetic and environmental factors in the configuration of the pathophysiological adaptation patterns.
本研究旨在综述经典和近期研究中遗传学和海拔高度对肺功能的影响。
系统检索了不同的科学研究数据库，使用了与肺容积、肺活量测定法、海拔和遗传学相关的关键词。
这项工作的结果分为三个部分。首先，介绍基因与肺功能的关系。其次，综述了与千年来居住在高海拔地区的人的呼吸适应相关的遗传易感性。最后，介绍了在高海拔地区呼吸生理学的临时影响和长期适应。
目前，研究遗传、表观遗传和环境因素在病理生理适应模式形成中的相互作用时，关注遗传学和海拔高度对肺功能影响的研究工作具有重要意义。
