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新冠病毒低剂量辐射疗法需谨慎。

Caution warranted for low-dose radiation therapy for Covid-19.

机构信息

Department of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.

出版信息

Br J Radiol. 2021 Jan 1;94(1117):20200466. doi: 10.1259/bjr.20200466. Epub 2020 Oct 28.

DOI:10.1259/bjr.20200466
PMID:33112664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7774700/
Abstract

Covid-19 is a morbid respiratory disease that has caused desperate times on a global scale due to the lack of any effective medical treatment. Some in the radiation community are actively proposing low-dose radiation therapy (LDRT) for managing the viral pneumonia associated with Covid-19. This commentary provides a rationale for exercising caution against such a decision as the efficacy of LDRT for viral diseases is unknown, while its long-term adverse risks are well known.

摘要

Covid-19 是一种严重的呼吸道疾病,由于缺乏有效的治疗方法,在全球范围内造成了严重的后果。一些放射界人士积极提议使用低剂量辐射疗法(LDRT)来治疗与 Covid-19 相关的病毒性肺炎。本评论提供了反对这一决定的理由,因为 LDRT 治疗病毒病的疗效尚不清楚,但其长期不良风险是众所周知的。

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A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.SARS-CoV-2 感染和发病机制的小鼠模型。
Cell Host Microbe. 2020 Jul 8;28(1):124-133.e4. doi: 10.1016/j.chom.2020.05.020. Epub 2020 May 27.
2
Flying by the seat of our pants: is low dose radiation therapy for COVID-19 an option?凭经验行事:低剂量放射疗法治疗新冠病毒肺炎是一种选择吗?
Int J Radiat Biol. 2020 Oct;96(10):1219-1223. doi: 10.1080/09553002.2020.1767314. Epub 2020 May 26.
3
Low dose radiation therapy for COVID-19 pneumonia: A double-edged sword.低剂量放射治疗新冠病毒肺炎:一把双刃剑。
Radiother Oncol. 2020 Jun;147:224-225. doi: 10.1016/j.radonc.2020.04.026. Epub 2020 Apr 20.
4
Is low dose radiation therapy a potential treatment for COVID-19 pneumonia?低剂量放射治疗是否是新冠病毒肺炎的一种潜在治疗方法?
Radiother Oncol. 2020 Jun;147:221. doi: 10.1016/j.radonc.2020.04.004. Epub 2020 Apr 6.
5
Low dose radiation therapy for COVID-19 pneumonia: is there any supportive evidence?低剂量放射治疗新冠病毒肺炎:有支持性证据吗?
Int J Radiat Biol. 2020 Oct;96(10):1224-1227. doi: 10.1080/09553002.2020.1762020. Epub 2020 May 6.
6
Compassionate Use of Remdesivir for Patients with Severe Covid-19.瑞德西韦在治疗重症 COVID-19 患者中的同情使用。
N Engl J Med. 2020 Jun 11;382(24):2327-2336. doi: 10.1056/NEJMoa2007016. Epub 2020 Apr 10.
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First statement on preparation for the COVID-19 pandemic in large German Speaking University-based radiation oncology departments.关于大型德语区大学放射肿瘤学部门为 COVID-19 大流行做准备的首次声明。
Radiat Oncol. 2020 Apr 7;15(1):74. doi: 10.1186/s13014-020-01527-1.
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