Yoshimura Kosuke, Ohge Hiroki, Shimada Norimitsu, Uegami Shinnosuke, Watadani Yusuke, Nakashima Ikki, Hirano Toshinori, Kitagawa Hiroki, Kaiki Yuki, Takahashi Shinya
Department of Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, Hiroshima, 734-8551, Japan.
Department of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, Hiroshima, 737-0023, Japan.
Surg Case Rep. 2020 Oct 28;6(1):275. doi: 10.1186/s40792-020-01048-9.
Chronic idiopathic colonic pseudo-obstruction (CICP) is a rare disease, defined as a condition of the chronically damaged colon, without obstruction or stenosis, and a pathological abnormality in the myenteric plexus. To date, there is no effective medication for CICP, and existing medication is not useful, making surgery the only effective treatment. Laparoscopic surgery is useful for reducing surgical trauma and postoperative adhesion. Herein, we report a patient with recurrent laxative-uncontrolled bowel obstruction, who underwent successful treatment with laparoscopic total colectomy based on preoperative detailed evaluation of bowel function.
A 77-year-old female patient without any past abdominal or psychological medical history was referred to our hospital because of chronic constipation and abdominal pain. Contrast-enhanced computed tomography, barium enema, cine magnetic resonance imaging, and defecography indicated an enlarged colon from the cecum to the transverse colon (proximal to the splenic flexure) without apparent mechanical obstruction, and a collapsed colon from the descending colon to the rectum, with reduced peristalsis. Bowel movements of the rectum and anorectal function were normal. Based on these findings, we diagnosed CICP and performed laparoscopic total colectomy and ileo-rectal anastomosis in this case. Postoperative recovery was good, without the need for postoperative laxatives. Pathologically, no degeneration of the muscle layers or Auerbach's plexus was found in the resected specimen.
Surgery is the only effective treatment for patients with CICP. Careful imaging before surgery is important for detecting the extent of excision required. This will reduce the need for additional surgery due to symptom relapse in the remnant colon. However, continued observation of the patient is required.
慢性特发性结肠假性梗阻(CICP)是一种罕见疾病,定义为结肠长期受损,无梗阻或狭窄,且肌间神经丛存在病理异常。迄今为止,尚无治疗CICP的有效药物,现有药物也无效,因此手术是唯一有效的治疗方法。腹腔镜手术有助于减少手术创伤和术后粘连。在此,我们报告一例复发性泻药难治性肠梗阻患者,该患者在术前对肠功能进行详细评估后,接受腹腔镜全结肠切除术并获得成功治疗。
一名77岁女性患者,既往无腹部或心理病史,因慢性便秘和腹痛转诊至我院。对比增强计算机断层扫描、钡灌肠、电影磁共振成像和排粪造影显示,从盲肠到横结肠(脾曲近端)结肠扩张,无明显机械性梗阻,而降结肠至直肠结肠塌陷,蠕动减弱。直肠排便和肛门直肠功能正常。基于这些发现,我们诊断为CICP,并对该病例实施了腹腔镜全结肠切除术和回肠直肠吻合术。术后恢复良好,无需术后使用泻药。病理检查发现,切除标本中肌肉层或奥尔巴赫神经丛无退变。
手术是CICP患者唯一有效的治疗方法。术前仔细的影像学检查对于确定所需切除范围很重要。这将减少因残留结肠症状复发而需要再次手术的情况。然而,仍需对患者进行持续观察。