Department of Cardiology, Health Sciences University, Adana Training and Research Hospital, Adana, Turkey.
Braz J Cardiovasc Surg. 2021 Jun 1;36(3):372-378. doi: 10.21470/1678-9741-2020-0208.
In this study, we aimed to investigate the impact of transcatheter aortic valve implantation (TAVI) on serum apelin levels in patients with severe symptomatic aortic valve stenosis (AS).
Forty-six consecutive patients (76.9±7.4 years, n=27 women) who underwent TAVI and 45 age- and sex-matched control subjects were included in the study. Echocardiographic parameters, serum apelin, pro-brain natriuretic peptide (Pro-BNP), and troponin I levels were compared between the groups. In addition, the preprocedural and first-month follow-up echocardiographic parameters and serum apelin values of TAVI patients were compared.
Serum median troponin I and Pro-BNP levels were significantly higher and serum apelin levels were significantly lower in TAVI patients before TAVI procedure than in the control subjects (P<0.001, for all). Median troponin I and Pro-BNP levels were significantly decreased and apelin levels were significantly increased after TAVI procedure compared to the peri-procedural levels. There was a significant and moderate negative correlation between Pro-BNP and apelin levels measured before and after TAVI procedure. A statistically significant and strong negative correlation was found between aortic valve area and Pro-BNP level before TAVI procedure, while a statistically significant but weak positive correlation was found between valve area and apelin level.
In our study, apelin levels were significantly lower and Pro-BNP levels were higher in AS patients compared with the control group. Moreover, after TAVI procedure, a significant increase in apelin levels and a significant decrease in Pro-BNP levels were observed. There was also a negative and moderate correlation between apelin and Pro-BNP levels.
本研究旨在探讨经导管主动脉瓣植入术（TAVI）对严重症状性主动脉瓣狭窄（AS）患者血清apelin 水平的影响。
本研究纳入了 46 例连续接受 TAVI 治疗的患者（76.9±7.4 岁，女性 27 例）和 45 名年龄和性别匹配的对照组患者。比较两组患者的超声心动图参数、血清 apelin、脑钠肽前体（Pro-BNP）和肌钙蛋白 I 水平。此外，还比较了 TAVI 患者术前和术后 1 个月的超声心动图参数和血清 apelin 值。
TAVI 患者术前的血清肌钙蛋白 I 和 Pro-BNP 水平显著高于对照组，而血清 apelin 水平显著低于对照组（P<0.001，均为 P<0.001）。TAVI 术后，血清肌钙蛋白 I 和 Pro-BNP 水平显著降低，apelin 水平显著升高，与围手术期水平相比差异具有统计学意义（均为 P<0.001）。TAVI 术前和术后测量的 Pro-BNP 和 apelin 水平之间存在显著的中度负相关。TAVI 术前主动脉瓣面积与 Pro-BNP 水平呈显著负相关，而与 apelin 水平呈显著正相关。
与对照组相比，AS 患者的 apelin 水平显著降低，Pro-BNP 水平显著升高。此外，TAVI 术后，apelin 水平显著升高，Pro-BNP 水平显著降低，且 apelin 与 Pro-BNP 水平之间呈负相关且中度相关。
