甲状旁腺激素对动物模型牙周愈合的影响：系统评价。
Influence of parathyroid hormone on periodontal healing in animal models: A systematic review.
机构信息
INSERM, UMR 1260 'Osteoarticular and Dental Regenerative Nanomedicine', Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
INSERM, UMR 1260 'Osteoarticular and Dental Regenerative Nanomedicine', Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Faculté de Chirurgie Dentaire, Université de Strasbourg, Strasbourg, France; Pôle de Médecine et de Chirurgie Bucco-Dentaires, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
出版信息
Arch Oral Biol. 2020 Dec;120:104932. doi: 10.1016/j.archoralbio.2020.104932. Epub 2020 Oct 6.
OBJECTIVES
The purpose of this systematic review was to determine the potential interest of parathyroid hormone (PTH) as an adjunct to periodontal treatment based on studies performed in rodents.
MATERIALS & METHODS: Electronic databases (MEDLINE, Web of Science) were searched up to December 2019. Studies assessing the impact of PTH administration in experimental periodontitis in rodents have been identified.
RESULTS
Amongst the 247 identified articles, 10 met the inclusion criteria and were included in this systematic review. Experimental periodontitis was mainly induced by ligature placement or surgically with a dental bur. All studies considered bone healing after PTH administration at different frequencies as primary outcome. Results showed that an intermittent administration of PTH promoted bone healing and neovascularization. Nevertheless, a decrease of soft tissue inflammation was also observed.
CONCLUSION
Intermittent administration of PTH appears to enhance significantly periodontal healing and to promote alveolar bone regeneration. However, due to the risk of side effects, the development of scaffolds allowing its local and time-controlled delivery is of importance.
目的
本系统评价旨在基于啮齿动物研究，确定甲状旁腺激素 (PTH) 作为牙周治疗辅助手段的潜在意义。
材料与方法
检索了截至 2019 年 12 月的电子数据库（MEDLINE、Web of Science）。确定了评估 PTH 给药对啮齿动物实验性牙周炎影响的研究。
结果
在 247 篇已识别的文章中，有 10 篇符合纳入标准，并被纳入本系统评价。实验性牙周炎主要通过结扎或牙钻手术诱导。所有研究均考虑了 PTH 给药后不同频率的骨愈合作为主要结局。结果表明，PTH 的间歇性给药可促进骨愈合和新生血管形成。然而，也观察到软组织炎症减少。
结论
PTH 的间歇性给药似乎可显著促进牙周愈合和牙槽骨再生。然而，由于存在副作用风险，开发允许其局部和时间控制释放的支架非常重要。
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