INSERM, UMR 1260 'Osteoarticular and Dental Regenerative Nanomedicine', Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
Periodontology, Dental Faculty, University of Strasbourg, Strasbourg, France.
Adv Exp Med Biol. 2021;1341:67-87. doi: 10.1007/5584_2020_593.
Periodontitis is an infectious inflammatory disease characterized by clinical attachment loss and tooth supporting tissue destruction. As exosomes demonstrated pro-regenerative ability, their use in periodontal treatment has been suggested. The aim of this systematic review is to gather and summarize the most recent data regarding exosomes to determine their potential impact in bone and periodontal regeneration. Electronic databases (Pubmed, Web of Science) were searched up to February 2020. Studies assessing the impact of exosomes administration in experimental bone and periodontal defects have been identified according to PRISMA guidelines. Among the 183 identified articles, 16 met the inclusion criteria and were included in this systematic review. Experimental bone defects were mainly surgically induced with a dental bur or distraction tools. All studies considered bone healing after exosomes administration as the primary outcome. Results showed that mesenchymal stem cells derived exosomes administration promoted bone healing and neovascularization. Nevertheless, a dose-effect relationship was observed. Exosomes administration appears to promote significantly the bone healing and periodontal regeneration. However, only a limited number of studies have been carried out so far and the optimized protocols in this context need to be evaluated.
牙周炎是一种感染性炎症性疾病，其特征为临床附着丧失和牙齿支持组织破坏。由于外泌体表现出促再生能力，因此有人提出将其用于牙周病治疗。本系统综述的目的是收集和总结有关外泌体的最新数据，以确定其在骨和牙周再生中的潜在影响。电子数据库（Pubmed、Web of Science）检索截至 2020 年 2 月。根据 PRISMA 指南确定了评估外泌体给药对实验性骨和牙周缺损影响的研究。在 183 篇确定的文章中，有 16 篇符合纳入标准并被纳入本系统综述。实验性骨缺损主要通过牙钻或牵引工具手术诱导。所有研究均将外泌体给药后的骨愈合作为主要结局。结果表明，间充质干细胞来源的外泌体给药可促进骨愈合和新生血管形成。然而，观察到了剂量效应关系。外泌体给药似乎可显著促进骨愈合和牙周再生。然而，目前为止仅开展了有限数量的研究，需要对此类研究的最佳方案进行评估。
