Li Dan, Xie April Hui, Liu Zhichao, Li Dongying, Ning Baitang, Thakkar Shraddha, Tong Weida, Xu Joshua
Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Pharmaceutics. 2020 Oct 25;12(11):1021. doi: 10.3390/pharmaceutics12111021.
Numerous prescription drugs' labeling contains pharmacogenomic (PGx) information to aid health providers and patients in the safe and effective use of drugs. However, clinical studies for such PGx biomarkers and related drug doses are generally not conducted in diverse ethnic populations. Thus, it is urgently important to incorporate PGx information with genetic characteristics of racial and ethnic minority populations and utilize it to promote minority health. In this project a bioinformatics approach was developed to enhance the collection of PGx information related to ethnic minorities to pave the way toward understanding the population-wide utility of PGx information. To address this challenge, we first gathered PGx information from drug labels. Second, we extracted data on the allele frequency information of genetic variants in ethnic minority groups from public resources. Then, we collected published research articles on PGx biomarkers and related drugs for reference. Finally, the data were integrated and formatted to build a new PGx database containing information on known drugs and biomarkers for ethnic minority groups. This database provides scientific information needed to evaluate available PGx information to enhance drug dose selection and drug safety for ethnic minority populations.
许多处方药的标签包含药物基因组学（PGx）信息，以帮助医疗服务提供者和患者安全有效地使用药物。然而，此类PGx生物标志物和相关药物剂量的临床研究通常不在不同种族人群中进行。因此，将PGx信息与少数族裔人群的遗传特征相结合并利用它来促进少数族裔健康变得至关重要。在这个项目中，开发了一种生物信息学方法，以加强与少数族裔相关的PGx信息的收集，为理解PGx信息在全人群中的效用铺平道路。为应对这一挑战，我们首先从药物标签中收集PGx信息。其次，我们从公共资源中提取少数族裔群体中基因变异的等位基因频率信息数据。然后，我们收集已发表的关于PGx生物标志物和相关药物的研究文章以供参考。最后，对数据进行整合和格式化，以建立一个新的PGx数据库，其中包含少数族裔群体已知药物和生物标志物的信息。该数据库提供了评估现有PGx信息所需的科学信息，以加强少数族裔人群的药物剂量选择和药物安全性。
