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CIViC 是一个社区知识库,用于专家众包对癌症变异的临床解释。

CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.

机构信息

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.

Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.

出版信息

Nat Genet. 2017 Jan 31;49(2):170-174. doi: 10.1038/ng.3774.

Abstract

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. CIViC is committed to open-source code, open-access content, public application programming interfaces (APIs) and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.

摘要

CIViC 是一个专家众包的癌症变异临床解读知识库,描述了所有类型的遗传性和体细胞变异的治疗、预后、诊断和易感性相关性。CIViC 致力于开源代码、开放获取内容、公共应用程序编程接口 (API) 和支持证据的出处,以允许透明地创建当前和准确的变异解读,用于癌症精准医学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42e0/5367263/20e68849e585/nihms851295f1.jpg

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