Molecular Oncology, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia.
Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Molecules. 2020 Oct 23;25(21):4905. doi: 10.3390/molecules25214905.
Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from . Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug.
人参皂苷 Rg3（Rg3）是从 中提取的人参皂苷类化学物质的一员。与其他人参皂苷一样，Rg3 有两个差向异构体：20(S)-人参皂苷 Rg3（SRg3）和 20(R)-人参皂苷 Rg3（RRg3）。由于其抗癌特性，Rg3 是一种有趣的分子。Rg3 的抗癌特性之一是抗血管生成作用。本综述描述了关于 Rg3 的作用和有效剂量范围的争议，总结了 Rg3 对血管生成作用的疗效证据，并提出了 Rg3 可能是前药的可能性。
