从官能化异腈出发通过钯催化的C-H键氨基亚胺基化反应制备1-氨基-3,4-二氢异喹啉
Access to 1-amino-3,4-dihydroisoquinolines palladium-catalyzed C-H bond aminoimidoylation reaction from functionalized isocyanides.
作者信息
Xiong Zhuang, Cai Panyuan, Mei Yingshuang, Wang Jian
机构信息
School of Biotechnology and Sciences, Wuyi University Jiangmen Guangdong 529090 P. R. China
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University Wuhu Anhui 241000 P. R. China
出版信息
RSC Adv. 2019 Dec 18;9(72):42072-42076. doi: 10.1039/c9ra09139d.
Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C-H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C-H bond activation were realized with C-N and C-C bonds formation in one step under redox neutral conditions, employing -benzoyl hydroxylamines as electrophilic amino sources.
通过钯催化α-苄基-α-异氰基乙酸酯的分子内C-H键氨基亚氨基化反应，已开发出一种有效合成1-氨基-3,4-二氢异喹啉的方法。在氧化还原中性条件下，以苯甲酰羟胺作为亲电氨基源，一步实现了异氰化物的连续插入和C-H键活化，并形成了C-N键和C-C键。
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