Harinasuta T, Bunnag D, Vanijanond S, Charoenlarp P, Suntharasmai P, Chitamas S, Sheth U K, Wernsdorfer W H
Bull World Health Organ. 1987;65(3):363-7.
A total of 89 adult male Thai patients who had acute, uncomplicated falciparum malaria were treated in a double-blind randomized trial with a single oral dose of two or three tablets, each consisting of 250 mg mefloquine, 500 mg sulfadoxine, and 25 mg pyrimethamine (MSP). The two-tablet regimen produced a cure rate (S response) of 93%, the three-tablet regimen a cure rate of 98%. The mean duration of parasitaemia for the two- and three-tablet groups was 50 and 29 hours, respectively, while the mean duration of fever was 43 and 40 hours, respectively. Differences between the groups were not statistically significant. Tolerance was good at both dose levels. The main side-effects were abdominal discomfort, nausea, vomiting, dizziness, and diarrhoea, but these were mild, transient, and required no specific treatment. The results of haematological and biochemical investigations and of urinalysis revealed no drug-related changes following administration of MSP. The electrocardiograms of some patients revealed sinus bradycardia or sinus arrythmia, but these conditions were transient, symptomless, and clinically not significant.
在一项双盲随机试验中，共89名患有急性、无并发症恶性疟原虫疟疾的成年泰国男性患者接受了单剂量口服两片或三片药物的治疗，每片药物含有250毫克甲氟喹、500毫克磺胺多辛和25毫克乙胺嘧啶（MSP）。两片药物治疗方案的治愈率（S反应）为93%，三片药物治疗方案的治愈率为98%。两片和三片药物组的平均寄生虫血症持续时间分别为50小时和29小时，而平均发热持续时间分别为43小时和40小时。两组之间的差异无统计学意义。两个剂量水平的耐受性均良好。主要副作用为腹部不适、恶心、呕吐、头晕和腹泻，但这些副作用较轻、短暂，无需特殊治疗。血液学和生化检查以及尿液分析结果显示，服用MSP后未出现与药物相关的变化。一些患者的心电图显示窦性心动过缓或窦性心律失常，但这些情况是短暂的、无症状的，临床上无显著意义。
