恶性疟原虫在连续培养中对甲氟喹敏感性的降低。
Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture.
作者信息
Brockelman C R, Monkolkeha S, Tanariya P
出版信息
Bull World Health Organ. 1981;59(2):249-52.
Abstract
Chloroquine-resistant P. falciparum, line FCK from Thailand, was tested for susceptibility to mefloquine in continuous culture. The drug resulted in 50% schizont inhibition at the level of 8.0 nmol/ml of culture when tested for the first time. After three months of discontinuous exposure to mefloquine at increasing levels, the sensitivity of the parasite decreased. A concentration as high as 128 nmol/ml eventually was required for 50% inhibition of growth.
摘要
对来自泰国的氯喹抗性恶性疟原虫株FCK进行了连续培养条件下对甲氟喹敏感性的检测。首次检测时，该药物在培养物浓度为8.0纳摩尔/毫升时导致50%的裂殖体抑制。在以递增水平间断接触甲氟喹三个月后，寄生虫的敏感性降低。最终需要高达128纳摩尔/毫升的浓度才能抑制50%的生长。
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