Department of Physiology, Faculty of Medicine and Nursery, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Innovation in Assisted Reproduction Group, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Int J Mol Sci. 2020 Oct 26;21(21):7943. doi: 10.3390/ijms21217943.
The renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that acts locally through different paracrine and autocrine mechanisms. In the male reproductive system, several components of this system have been observed in various organs and tissues, such as the testes, spermatozoa and seminal fluid. Some functions attributed to this local RAS are maintenance of seminal plasma electrolytes, regulation of steroidogenesis and spermatogenesis, and sperm functions. However, their specific actions in these locations are not fully understood. Therefore, a deep knowledge of the functions of the RAS at both the testicular and seminal levels could clarify its roles in male infertility and sperm physiology, and the different RAS elements could be used to design tools enabling the diagnosis and/or treatment of male infertility.
肾素-血管紧张素系统（RAS）是一个肽系统，主要因其在维持血压和电解质及体液平衡中的作用而闻名。然而，已经描述了一些组织和细胞具有内在的 RAS，通过不同的旁分泌和自分泌机制在局部发挥作用。在男性生殖系统中，该系统的几个成分已在各种器官和组织中观察到，如睾丸、精子和精液。该局部 RAS 的一些功能包括维持精液电解质、调节类固醇生成和精子发生以及精子功能。然而，它们在这些部位的具体作用尚不完全清楚。因此，深入了解 RAS 在睾丸和精液水平上的功能可以阐明其在男性不育和精子生理学中的作用，并且不同的 RAS 元素可以用于设计工具来诊断和/或治疗男性不育。
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