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环孢素A对棕色挪威大鼠自身免疫性肾小管间质性肾炎的影响。

Effect of cyclosporin A on autoimmune tubulointerstitial nephritis in the brown Norway rat.

作者信息

Giménez A, Leyva-Cobián F, Fierro C, Río M, Bricio T, Mampaso F

机构信息

Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain.

出版信息

Clin Exp Immunol. 1987 Sep;69(3):550-6.

PMID:3311496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542380/
Abstract

The effect of cyclosporin A (CyA) on the development of tubulointerstitial nephritis (TIN) in the brown Norway (BN) rat was assessed. All manifestations of TIN were prevented in rats by subcutaneously injected CyA (20 mg/kg/day). A short 7-day course of CyA beginning the day before immunization suppressed the primary and ongoing antibody response. In addition, delayed CyA treatment (starting on day 10 after immunization), when antibody response was established, drastically reduced the levels of serum anti-TBM IgG, and abrogated the interstitial inflammatory cell response, in spite of persistent kidney-bound TBM antibodies. These results indicate that CyA has a therapeutic effect on the BN rat model of TIN.

摘要

评估了环孢素A（CyA）对棕色挪威（BN）大鼠肾小管间质性肾炎（TIN）发展的影响。皮下注射CyA（20mg/kg/天）可预防大鼠TIN的所有表现。在免疫前一天开始的为期7天的短疗程CyA抑制了初次和持续的抗体反应。此外，在抗体反应建立后进行延迟的CyA治疗（免疫后第10天开始），尽管肾脏中仍存在结合TBM的抗体，但血清抗TBM IgG水平大幅降低，并且消除了间质炎症细胞反应。这些结果表明CyA对TIN的BN大鼠模型具有治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dd3/1542380/51734b35e387/clinexpimmunol00108-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dd3/1542380/3b71fcd3b153/clinexpimmunol00108-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dd3/1542380/51734b35e387/clinexpimmunol00108-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dd3/1542380/3b71fcd3b153/clinexpimmunol00108-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dd3/1542380/51734b35e387/clinexpimmunol00108-0072-a.jpg

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引用本文的文献

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3
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本文引用的文献

1
Immunosuppressive effect of cyclosporin A in two lymphocyte transfer models in rats: comparison of in vivo and in vitro treatment.环孢素A在大鼠两种淋巴细胞转移模型中的免疫抑制作用：体内与体外治疗的比较
Immunobiology. 1982 Dec;163(5):470-83. doi: 10.1016/S0171-2985(82)80061-2.
2
Suppression of delayed-type hypersensitivity reactions and lymphokine production by cyclosporin A in the mouse.环孢菌素A对小鼠迟发型超敏反应和淋巴因子产生的抑制作用。
Clin Exp Immunol. 1983 Jun;52(3):599-606.
3
Mechanism of T cell activation: role and functional relationship of HLA-DR antigens and interleukins.
Clin Exp Immunol. 1991 Jul;85(1):28-32. doi: 10.1111/j.1365-2249.1991.tb05677.x.
T细胞激活机制：HLA - DR抗原与白细胞介素的作用及功能关系
Immunol Rev. 1982;63:73-110. doi: 10.1111/j.1600-065x.1982.tb00412.x.
4
Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agents.环孢素A治疗对全身用皮质类固醇和细胞毒性药物耐药的眼内炎性疾病。
Am J Ophthalmol. 1983 Sep;96(3):275-82. doi: 10.1016/s0002-9394(14)77814-6.
5
Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset.环孢素免疫抑制对近期发病的胰岛素依赖型糖尿病的影响。
Science. 1984 Mar 30;223(4643):1362-7. doi: 10.1126/science.6367043.
6
Marked reduction of DNA antibody production and glomerulopathy in thymulin (FTS-Zn) or cyclosporin A treated (NZB X NZW) F1 mice.在胸腺素（FTS-Zn）或环孢素A处理的（新西兰黑鼠×新西兰白鼠）F1代小鼠中，DNA抗体产生和肾小球病变显著减少。
Clin Exp Immunol. 1983 Nov;54(2):359-65.
7
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J Immunol. 1983 Sep;131(3):1268-73.
8
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Immunol Rev. 1982;65:5-22. doi: 10.1111/j.1600-065x.1982.tb00425.x.
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