环孢素A对棕色挪威大鼠自身免疫性肾小管间质性肾炎的影响。
Effect of cyclosporin A on autoimmune tubulointerstitial nephritis in the brown Norway rat.
作者信息
Giménez A, Leyva-Cobián F, Fierro C, Río M, Bricio T, Mampaso F
机构信息
Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain.
出版信息
Clin Exp Immunol. 1987 Sep;69(3):550-6.
The effect of cyclosporin A (CyA) on the development of tubulointerstitial nephritis (TIN) in the brown Norway (BN) rat was assessed. All manifestations of TIN were prevented in rats by subcutaneously injected CyA (20 mg/kg/day). A short 7-day course of CyA beginning the day before immunization suppressed the primary and ongoing antibody response. In addition, delayed CyA treatment (starting on day 10 after immunization), when antibody response was established, drastically reduced the levels of serum anti-TBM IgG, and abrogated the interstitial inflammatory cell response, in spite of persistent kidney-bound TBM antibodies. These results indicate that CyA has a therapeutic effect on the BN rat model of TIN.
评估了环孢素A（CyA）对棕色挪威（BN）大鼠肾小管间质性肾炎（TIN）发展的影响。皮下注射CyA（20mg/kg/天）可预防大鼠TIN的所有表现。在免疫前一天开始的为期7天的短疗程CyA抑制了初次和持续的抗体反应。此外，在抗体反应建立后进行延迟的CyA治疗（免疫后第10天开始），尽管肾脏中仍存在结合TBM的抗体，但血清抗TBM IgG水平大幅降低，并且消除了间质炎症细胞反应。这些结果表明CyA对TIN的BN大鼠模型具有治疗作用。
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