Thoenes G H, Umscheid T, Sitter T, Langer K H
Medizinische Klinik Innenstadt, University of Munich, F.R.G.
Immunol Lett. 1987 Aug;15(4):301-6. doi: 10.1016/0165-2478(87)90132-5.
Tubulointerstitial nephritis, regularly induced in Brown Norway rats by autosensitization with tubular basement membranes, appeared acutely at about 10 days and was completely inhibited by Cyclosporin A (CyA) when this was given before and at the time of onset of the disease. It did not recur after the end of therapy. In spite of this disease inhibition, autoantibodies against tubular basement membranes persisted in the circulation and in the kidney. It is therefore suggested that it is not so much the antibodies that are the decisive factors in the pathogenesis of this and other autoimmune diseases but, rather cellular factors that are directly influenced by CyA. Although in this model CyA application was a preventive measure, the experiments provide a cogent reason for the application of CyA as early as possible in acute and seriously damaging diseases.
通过用肾小管基底膜进行自身致敏，可在棕色挪威大鼠中规律性地诱发肾小管间质性肾炎，该病大约在10天时急性出现，当在疾病发作前及发作时给予环孢素A（CyA）时，可被其完全抑制。治疗结束后该病未复发。尽管疾病得到了抑制，但针对肾小管基底膜的自身抗体仍持续存在于循环系统和肾脏中。因此，有人提出，在这种及其他自身免疫性疾病的发病机制中，起决定性作用的并非抗体，而是直接受CyA影响的细胞因子。尽管在该模型中应用CyA是一种预防措施，但这些实验为在急性和严重破坏性疾病中尽早应用CyA提供了有力依据。
