University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark.
Biomed J. 2020 Oct;43(5):393-398. doi: 10.1016/j.bj.2020.10.003. Epub 2020 Oct 10.
This issue of the Biomedical Journal acquaints us with the compelling hypothesis that the vascular glycocalyx lies at the intersection of severe COVID-19 risk factors and damages, and the ways used by artificial intelligence to predict interactions between SARS-CoV-2 and human proteins. Furthermore, we explore the antiviral potential of valinomycin and the long list of COVID-19-related clinical trials, and learn how (not) to fix a broken femoral head. Last but not least, we get to enjoy the tale of the cellular oxygen-sensing system as well as the role of the host complement system during Leptospira infection, and learn that SARS-CoV-2 can sometimes come with a pathogenic plus one.
本期《生物医学期刊》让我们了解到一个引人注目的假设，即血管糖萼位于严重 COVID-19 风险因素和损害的交叉点，以及人工智能用于预测 SARS-CoV-2 与人类蛋白质相互作用的方法。此外，我们探讨了缬氨霉素的抗病毒潜力以及与 COVID-19 相关的临床试验清单，并了解如何（不）修复破损的股骨头。最后但同样重要的是，我们欣赏细胞氧感应系统的故事以及宿主补体系统在钩端螺旋体感染过程中的作用，并了解到 SARS-CoV-2 有时可能会带来一个致病附加物。
