• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

伴有套细胞淋巴瘤的 IgA 肾病伴 IgA2 沉积为主型

IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma.

机构信息

The Second Department of Internal Medicine, University of Toyama, Japan.

Department of Hematology, University of Toyama, Japan.

出版信息

Intern Med. 2021 Apr 15;60(8):1243-1250. doi: 10.2169/internalmedicine.6099-20. Epub 2020 Oct 28.

DOI:10.2169/internalmedicine.6099-20
PMID:33116018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8112979/
Abstract

Malignant lymphoma is rarely complicated by secondary IgA nephropathy. We encountered a 74-year-old man with rapidly progressive glomerulonephritis due to IgA nephropathy with predominant deposition of IgA2, instead of IgA1, in the glomerulus that was eventually diagnosed as secondary IgA nephropathy due to mantle cell lymphoma. Renal impairment was improved by chemotherapy for the mantle cell lymphoma. IgA came from the colonic mucosa that was stimulated by the infiltrated lymphoma cells, instead of the tumor itself. We should consider mantle cell lymphoma as a cause of secondary IgA nephropathy, although its prevalence may not be very high.

摘要

恶性淋巴瘤很少并发继发性 IgA 肾病。我们遇到一位 74 岁男性，因 IgA 肾病导致快速进行性肾小球肾炎，其肾小球中主要沉积的是 IgA2，而非 IgA1，最终诊断为由于套细胞淋巴瘤引起的继发性 IgA 肾病。针对套细胞淋巴瘤的化疗改善了肾功能损害。IgA 来自于受浸润的淋巴瘤细胞刺激的结肠黏膜，而不是肿瘤本身。尽管其发病率可能不是很高，但我们应将套细胞淋巴瘤视为继发性 IgA 肾病的病因之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/86ba482b6c44/1349-7235-60-1243-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/d89d82c4b43f/1349-7235-60-1243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/7158fc49df7a/1349-7235-60-1243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/fe7cc3b7b61e/1349-7235-60-1243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/5ae4ab74167e/1349-7235-60-1243-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/4a8eb8612e18/1349-7235-60-1243-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/a549ac9ad977/1349-7235-60-1243-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/8c2c3ddc7175/1349-7235-60-1243-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/86ba482b6c44/1349-7235-60-1243-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/d89d82c4b43f/1349-7235-60-1243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/7158fc49df7a/1349-7235-60-1243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/fe7cc3b7b61e/1349-7235-60-1243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/5ae4ab74167e/1349-7235-60-1243-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/4a8eb8612e18/1349-7235-60-1243-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/a549ac9ad977/1349-7235-60-1243-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/8c2c3ddc7175/1349-7235-60-1243-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0674/8112979/86ba482b6c44/1349-7235-60-1243-g008.jpg

相似文献

1
IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma.伴有套细胞淋巴瘤的 IgA 肾病伴 IgA2 沉积为主型
Intern Med. 2021 Apr 15;60(8):1243-1250. doi: 10.2169/internalmedicine.6099-20. Epub 2020 Oct 28.
2
Combined Effects of the Serum IgA/C3 Ratio and Glomerular C3 Staining on the Renal Outcome in Adult Immunoglobulin A Nephropathy.血清 IgA/C3 比值与肾小球 C3 染色对成人 IgA 肾病肾脏结局的联合影响。
Kidney Blood Press Res. 2024;49(1):246-257. doi: 10.1159/000536114. Epub 2024 Feb 21.
3
Bendamustine for patients with indolent B cell lymphoid malignancies including chronic lymphocytic leukaemia.苯达莫司汀用于治疗惰性B细胞淋巴瘤患者，包括慢性淋巴细胞白血病。
Cochrane Database Syst Rev. 2012 Sep 12;2012(9):CD009045. doi: 10.1002/14651858.CD009045.pub2.
4
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
5
Pathogenic synonymous variation of the COL4A3 gene causing Alport syndrome comorbid with IgA deposition in a toddler: a case report.COL4A3基因致病性同义变异导致一名幼儿患阿尔波特综合征并伴有IgA沉积：一例病例报告
BMC Nephrol. 2025 Aug 27;26(1):493. doi: 10.1186/s12882-025-04416-5.
6
Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review.IgA肾病中异常的IgA1糖基化：一项系统评价。
PLoS One. 2016 Nov 21;11(11):e0166700. doi: 10.1371/journal.pone.0166700. eCollection 2016.
7
Dynamics of chromatin accessibility governing Gd-IgA1 synthesis in B cells associated with IgA nephropathy.与IgA肾病相关的B细胞中调控Gd-IgA1合成的染色质可及性动态变化
Exp Mol Med. 2025 Jul 23. doi: 10.1038/s12276-025-01505-1.
8
O-glycosylation of IgA1 and the pathogenesis of an autoimmune disease IgA nephropathy.IgA1 的 O-糖基化与自身免疫性疾病 IgA 肾病的发病机制。
Glycobiology. 2024 Sep 30;34(11). doi: 10.1093/glycob/cwae060.
9
SOCS1 improves abnormal IgA galactosylation in IgA nephropathy by regulating the TLR9/MyD88 pathway.信号转导和转录激活因子1通过调节Toll样受体9/髓样分化因子88通路改善IgA肾病中异常的IgA半乳糖基化。
Immunol Res. 2025 Aug 4;73(1):115. doi: 10.1007/s12026-025-09669-8.
10
Successful treatment of MPO-ANCA positive crescentic IgA nephropathy/IgA vasculitis with nephritis potentially triggered by a COVID-19 vaccine in a young adult female using corticosteroids, rituximab, and avacopan.在一名年轻成年女性中，使用皮质类固醇、利妥昔单抗和阿伐可泮成功治疗了可能由新冠疫苗引发的MPO-ANCA阳性新月体性IgA肾病/IgA血管炎伴肾炎。
CEN Case Rep. 2025 Apr 9. doi: 10.1007/s13730-025-00991-6.

引用本文的文献

1
A case of paraneoplastic IgA nephropathy with glomerular capillary IgA and galactose-deficient IgA1 deposition.伴有肾小球毛细血管 IgA 和半乳糖缺乏 IgA1 沉积的副肿瘤性 IgA 肾病 1 例。
CEN Case Rep. 2024 Apr;13(2):104-109. doi: 10.1007/s13730-023-00807-5. Epub 2023 Jul 11.

本文引用的文献

1
Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy.继发性IgA肾病与原发性IgA肾病具有相同的免疫特征。
Kidney Int Rep. 2019 Nov 6;5(2):165-172. doi: 10.1016/j.ekir.2019.10.012. eCollection 2020 Feb.
2
Paraneoplastic ANCA positive crescentic glomerulonephritis as presenting feature of Mantle Cell lymphoma a unique case.副肿瘤性抗中性粒细胞胞质抗体阳性新月体肾炎为表现的套细胞淋巴瘤 1 例报告
J Assoc Physicians India. 2020 Jan;68(1):75.
3
Immunostaining for galactose-deficient immunoglobulin A is not specific for primary immunoglobulin A nephropathy.
免疫染色法检测半乳糖缺乏免疫球蛋白 A 对于原发性免疫球蛋白 A 肾病不具有特异性。
Nephrol Dial Transplant. 2020 Dec 4;35(12):2123-2129. doi: 10.1093/ndt/gfz152.
4
Renal Dysfunction in Patients With Direct Infiltration by B-Cell Lymphoma.B细胞淋巴瘤直接浸润患者的肾功能障碍
Kidney Int Rep. 2019 Feb 12;4(5):688-697. doi: 10.1016/j.ekir.2019.02.008. eCollection 2019 May.
5
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.套细胞淋巴瘤：2019 年诊断、发病机制、预后和治疗的更新。
Am J Hematol. 2019 Jun;94(6):710-725. doi: 10.1002/ajh.25487. Epub 2019 Apr 19.
6
Paraneoplastic immunoglobulin A nephropathy and associated focal segmental glomerulosclerosis in asymptomatic low volume B-cell lymphoma - a case report.无症状低容量B细胞淋巴瘤伴副肿瘤性免疫球蛋白A肾病及相关局灶节段性肾小球硬化——病例报告
BMC Nephrol. 2018 Sep 10;19(1):224. doi: 10.1186/s12882-018-1034-y.
7
Secondary IgA nephropathy.继发性 IgA 肾病。
Kidney Int. 2018 Oct;94(4):674-681. doi: 10.1016/j.kint.2018.02.030. Epub 2018 May 24.
8
Antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis associated with mantle cell lymphoma.与套细胞淋巴瘤相关的抗中性粒细胞胞浆抗体阳性少免疫性肾小球肾炎
Clin Nephrol Case Stud. 2017 Feb 3;5:9-15. doi: 10.5414/CNCS109036. eCollection 2017.
9
IgA Nephropathy.IgA肾病
Clin J Am Soc Nephrol. 2017 Apr 3;12(4):677-686. doi: 10.2215/CJN.07420716. Epub 2017 Feb 3.
10
Angioimmunoblastic T-cell Lymphoma Associated with IgA Nephropathy.血管免疫母细胞性T细胞淋巴瘤合并IgA肾病
Intern Med. 2017;56(1):85-89. doi: 10.2169/internalmedicine.56.7315. Epub 2017 Jan 1.