Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kidney Int. 2018 Oct;94(4):674-681. doi: 10.1016/j.kint.2018.02.030. Epub 2018 May 24.
IgA nephropathy is the most common primary glomerulonephritis worldwide. Its frequent coexistence with inflammatory, infectious, or malignant processes raises the possibility of a pathologic rather than coincidental association. Major strides have been made to elucidate the underlying pathophysiologic events that culminate in the development of primary IgA nephropathy. Whether secondary forms of the disease share common pathways triggered by underlying disorders or different mechanisms leading to similar pathologic findings remains to be determined. In this article we describe the most frequent etiologies for secondary IgA nephropathy and review the available literature for the pathophysiology.
IgA 肾病是全球最常见的原发性肾小球肾炎。其常与炎症、感染或恶性过程共存，提示存在病理性而非偶然的关联。在阐明导致原发性 IgA 肾病发展的潜在病理生理事件方面已经取得了重大进展。继发性 IgA 肾病是否具有由潜在疾病触发的共同途径，或者导致类似病理发现的不同机制，仍有待确定。本文描述了继发性 IgA 肾病的最常见病因，并回顾了相关的病理生理学文献。
