Akter N, Nessa A, Sharmin A, Dipa M I, Israt S, Firoz S, Yeasmin F
Dr Nasrin Akter, M Phil Physiology (Thesis Part), Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:
Mymensingh Med J. 2020 Oct;29(4):779-783.
Chronic kidney disease (CKD) is a common condition in which there is a loss of kidney function over time. CKD is associated with increased risks of several co morbidities, not limited to but including cardiovascular disease and chronic renal failure. Hypercreatininemia is associated with low level of estimated glomerular filtration rate (eGFR) in chronic kidney diseased patients. Objective of the study was to assess the relationship of eGFR and serum creatinine in chronic kidney diseased patients in order to compare this parameter with healthy subjects. This analytical type of cross-sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2018 to June 2019. A total number of 200 subjects, age range (30-70 year) were included in this study. Among them, 100 healthy subjects were taken as control group (Group I) and 100 chronic kidney diseased patients were taken as study group (Group II). Control group (Group I) again subdivided into male healthy subject (Group IA) and female healthy subject (Group IB). Study group (Group II) also subdivided into male chronic kidney diseased patient (Group IIA) and female chronic kidney diseased patient (Group IIB). The results were calculated and analyzed by using SPSS. Data were expressed as mean(±SE) and statistical significance of difference among the group was calculated by unpaired Student's t-test. In this study we found that eGFR was significantly decreased and serum creatinine was significantly increased in study groups in comparison with control groups. Therefore, by this study we recommended that routine estimation of these parameters is important for prevention of complications related to chronic kidney disease.
慢性肾脏病（CKD）是一种常见病症，其肾功能会随时间逐渐丧失。CKD与多种合并症风险增加相关，不限于但包括心血管疾病和慢性肾衰竭。在慢性肾脏病患者中，血肌酐升高与估算肾小球滤过率（eGFR）降低有关。本研究的目的是评估慢性肾脏病患者中eGFR与血清肌酐的关系，以便将该参数与健康受试者进行比较。这种分析性横断面研究于2018年7月至2019年6月在孟加拉国迈门辛市迈门辛医学院生理学系开展。本研究共纳入200名受试者，年龄范围为30至70岁。其中，100名健康受试者作为对照组（第一组），100名慢性肾脏病患者作为研究组（第二组）。对照组（第一组）又细分为男性健康受试者（第一A组）和女性健康受试者（第一B组）。研究组（第二组）也细分为男性慢性肾脏病患者（第二A组）和女性慢性肾脏病患者（第二B组）。结果采用SPSS进行计算和分析。数据以均值（±标准误）表示，组间差异的统计学显著性通过非配对学生t检验计算。在本研究中，我们发现与对照组相比，研究组的eGFR显著降低，血清肌酐显著升高。因此，通过本研究我们建议，常规评估这些参数对于预防慢性肾脏病相关并发症很重要。
