Division of Breast Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Department of Breast Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Sci Rep. 2020 Oct 28;10(1):18534. doi: 10.1038/s41598-020-75398-7.
Breast-conserving surgery (BCS) is performed in patients with ductal carcinoma in situ (DCIS) because of the small size of the tumor. It is essential to know the quantitative extent of the tumor before performing this precise partial resection surgery. A three-dimensional printed (3DP) breast surgical guide (BSG) was developed using information obtained from supine magnetic resonance imaging (MRI) and 3D printing technology and it was used for treating patients with breast cancer. Here, we report our experience with the application of the BSG for patients with DCIS. Patients with breast cancer who underwent BCS from July 2017 to February 2019 were included in this study. The patients underwent partial resection with a supine-MRI based 3DP-BSG. A total of 102 BCS using 3DP-BSG were conducted, and 11 cases were DCIS. The patients' median age was 56 years (range, 38-69 years). The mean tumor diameter was 1.3 ± 0.9 cm. The median surgical time was 70 min (range, 40-88 min). All patients had tumor-free resection margins. The median distance from the tumor to the margin was 11 mm (range, 2-35 mm). Direct demarcation of the tumor extent in the breast and a pain-free procedure are the advantages of using 3DP-BSG in patients with DCIS.Trial registration: Clinical Research Information Service (CRIS) Identifier Number: KCT0002375, KCT0003043.
保乳手术（BCS）适用于患有导管原位癌（DCIS）的患者，因为肿瘤体积较小。在进行这种精确的部分切除手术之前，了解肿瘤的定量程度至关重要。使用来自仰卧位磁共振成像（MRI）和 3D 打印技术获得的信息开发了一种三维打印（3DP）乳房手术引导器（BSG），并将其用于治疗乳腺癌患者。在这里，我们报告了使用 BSG 治疗 DCIS 患者的经验。本研究纳入了 2017 年 7 月至 2019 年 2 月期间接受 BCS 的乳腺癌患者。患者接受了基于仰卧位 MRI 的 3DP-BSG 部分切除术。共进行了 102 例 3DP-BSG 的 BCS，其中 11 例为 DCIS。患者的中位年龄为 56 岁（范围，38-69 岁）。平均肿瘤直径为 1.3±0.9cm。中位手术时间为 70 分钟（范围，40-88 分钟）。所有患者均获得无肿瘤切缘。肿瘤到切缘的中位距离为 11mm（范围，2-35mm）。在 DCIS 患者中使用 3DP-BSG 的优势在于可以直接划定肿瘤范围并实现无痛手术。
临床研究信息服务（CRIS）标识符号：KCT0002375，KCT0003043。
