Long Noncoding RNA FBXL19-AS1 Expedites Cell Growth, Migration and Invasion in Cervical Cancer by miR-193a-5p/PIN1 Signaling.

BACKGROUND

Cervical cancer is one of the most prevalent malignancies in gynecology with increasing incidence in recent years. Long noncoding RNAs (lncRNAs) have been reported to regulate human cancers including cervical cancer. F-box and leucine-rich repeat protein 19 antisense RNA 1 () have been unmasked to exert carcinogenic functions in several cancers except cervical cancer.

AIM

Present study hammered at investigating the function and mechanism of in cervical cancer.

METHODS

RT-qPCR was utilized to test gene expression. EdU staining, colony formation, transwell, flow cytometry and TUNEL assays were applied for measuring the impact of on cervical cancer cell functions. Moreover, RIP, RNA pull-down and luciferase reporter assays were utilized for detecting the correlations among , and (peptidylprolyl cis/trans isomerase, NIMA-interacting 1).

RESULTS

exhibited elevated expression in cervical cancer tissues and cells. Silencing repressed cell proliferation through arresting cell cycle and stimulating apoptosis, and losing also restrained cell migration and invasion. Also, we discovered as a sponge, while was a tumor inhibitor in cervical cancer. Further, was proved as the target, and augmented expression in cervical cancer via sequestering . Of note, accelerated the progression of cervical cancer, and its upregulation counteracted the impacts of depleted on cervical cancer cell functions.

CONCLUSION

contributes to malignant phenotypes in cervical cancer by sponging and regulating .