Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Int Health. 2021 Jul 3;13(4):367-373. doi: 10.1093/inthealth/ihaa083.
Type 2 diabetes mellitus (T2DM) is a global health problem. Early identification of those at risk is necessary to prevent its onset through lifestyle and pharmacologic interventions. T2DM is characterized by metabolic abnormalities, including protein metabolism. Evaluation of the amino acid profile might be beneficial for early assessment.
Liquid chromatography-mass spectrometry was performed to separate and quantify plasma amino acids from two groups of Thai individuals, patients with T2DM (n=103) and healthy individuals (n=104). Multivariate analysis was applied to compare free amino acid levels between groups. Subgroup analyses of patients with T2DM were performed to assess the association between amino acid profiles and important T2DM clinical characteristics.
The multivariate analysis showed that glutamic acid was significantly associated with T2DM (OR 1.113, 95% CI 1.006 to 1.231) and results from the subgroup analyses showed that this correlation was significant in all subgroups of patients (p<0.05).
This finding needs to be confirmed in larger groups of patients with T2DM to explore glutamic acid as a biomarker for early prevention in particular at-risk groups. An in-depth understanding of the involvement of glutamic acid in T2DM could enhance our understanding of the disease and potentially provide novel interventions.
2 型糖尿病（T2DM）是一个全球性的健康问题。通过生活方式和药物干预来预防其发病，早期识别高危人群是必要的。T2DM 的特征是代谢异常，包括蛋白质代谢。评估氨基酸谱可能有助于早期评估。
采用液相色谱-质谱法分离和定量来自两组泰国个体的血浆氨基酸，一组是 T2DM 患者（n=103），另一组是健康个体（n=104）。应用多变量分析比较两组之间的游离氨基酸水平。对 T2DM 患者进行亚组分析，评估氨基酸谱与重要 T2DM 临床特征之间的关系。
多变量分析显示，谷氨酸与 T2DM 显著相关（OR 1.113，95% CI 1.006 至 1.231），亚组分析结果表明，这种相关性在所有 T2DM 患者亚组中均具有统计学意义（p<0.05）。
需要在更大的 T2DM 患者群体中证实这一发现，以探索谷氨酸作为特定高危人群早期预防的生物标志物。深入了解谷氨酸在 T2DM 中的作用可能会增强我们对该疾病的理解，并为潜在的新干预措施提供依据。
