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比较 Muller 肌结膜切除术治疗轻度/中度与重度退行性腱膜性上睑下垂的结果。

Comparing the outcome of Muller's muscle conjunctival resection for mild/moderate versus severe involutional aponeurotic ptosis.

机构信息

Istanbul Beyoglu Eye Research and Training Hospital, Istanbul, Turkey.

出版信息

Eur J Ophthalmol. 2021 Nov;31(6):3436-3441. doi: 10.1177/1120672120963454. Epub 2020 Oct 29.

DOI:10.1177/1120672120963454
PMID:33118399
Abstract

AIMS

To compare predictability of the outcomes of Muller's muscle conjunctiva resection (MMCR) in patients with severe versus mild/moderate involutional aponeurotic ptosis.

METHODS

This was a retrospective case-control study. All cases were recruited into the groups in terms of preoperative marginal reflex distance of upper eyelid (MRD-1). Group 1 consisted of patients with mild to moderate blepharoptosis was defined as an MRD-1 equal to 1.1 to 3 mm and Group 2 consisted of patients with severe blepharoptosis defined as MRD-1 ⩽ 1 mm. All patients underwent MMCR based on the response to phenylephrine and the amount of ptosis. MRD-1 obtained both manually and with ImageJ analysis program preoperatively and on the postoperative sixth month was compared. Successful surgical outcome criteria were defined as MRD-1 ⩾ 2.5 mm and inter-eyelid symmetry ⩽ 1 mm.

RESULTS

A total of 97 eyes of 83 participants met the inclusion criteria for this study (Group 1  = 50, Group 2  = 47). In terms of MRD-1 success rates were 88% in Group 1, and 70.2% in Group 2 ( = 0.03). Preoperative MRD-1 which was measured by ImageJ, and the amount of resected tissue in mm were the predictive data of surgical outcome by the logistic regression analysis (OR 6.45, 95% CI 1.82-22.78,  = 0.004, OR 2.47, 95% CI 1.05-5.80,  = 0.037, respectively).

CONCLUSION

The surgical success of MMCR can be predicted via tissue resection length and preoperative MRD-1. Higher surgical success rates were obtained in cases with mild-moderate ptosis and clinically acceptable success rates were obtained in cases with severe ptosis.

摘要

目的

比较 Muller 肌结膜切除术(MMCR)治疗重度与轻度/中度退行性腱膜性上睑下垂的疗效预测。

方法

这是一项回顾性病例对照研究。所有病例均根据术前上睑缘切迹距离 1(MRD-1)分为两组。第 1 组(轻度至中度上睑下垂)定义为 MRD-1 为 1.1 至 3mm,第 2 组(重度上睑下垂)定义为 MRD-1 ⩽ 1mm。所有患者均根据对苯肾上腺素的反应和上睑下垂量行 MMCR。比较术前和术后第 6 个月手动和 ImageJ 分析程序测量的 MRD-1。成功的手术结果标准定义为 MRD-1 ⩾ 2.5mm 和睑裂对称性 ⩽ 1mm。

结果

本研究共纳入 83 名患者的 97 只眼(第 1 组 50 只,第 2 组 47 只)。第 1 组的 MRD-1 成功率为 88%,第 2 组为 70.2%( ⁇  = 0.03)。通过逻辑回归分析,ImageJ 测量的术前 MRD-1 和切除组织的毫米数是手术结果的预测数据(OR 6.45,95%CI 1.82-22.78, ⁇  = 0.004,OR 2.47,95%CI 1.05-5.80, ⁇  = 0.037)。

结论

MMCR 的手术成功率可通过组织切除长度和术前 MRD-1 预测。轻度至中度上睑下垂病例的手术成功率较高,重度上睑下垂病例的手术成功率也可接受。

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