Faculty of Medicine, University of Latvia; Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia.
Faculty of Medicine, University of Latvia, Riga, Latvia.
J Gastrointestin Liver Dis. 2020 Oct 27;29(4):523-528. doi: 10.15403/jgld-813.
Although a family history of cancer (FHC) can modify the lifestyle and attitudes towards participation in cancer screening programs, studies on this relationship show mixed results and vary across populations. The objectives of the study were to compare sociodemographic characteristics, history of gastrointestinal (GI) investigations and Helicobacter pylori eradication, and modifiable cancer risk factors between those with FHC and those with no FHC (NFHC), and to investigate the association between FHC and a history of GI investigations.
A total of 3,455 questionnaires from the pilot study of the "Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality (GISTAR study)" in Latvia were analysed. We compared sociodemographic characteristics and history of GI investigations between participants with self- reported FHC and NFHC. Binary logistic regression models adjusted for socio-demographic characteristics and modifiable cancer risk factors were built for a FHC and each GI investigation.
Participants with a FHC were more likely to be women, have a higher education and less likely to have harmful habits (smoking, alcohol consumption) than those with NFHC. Participants with a FHC were approximately twice as likely to report recent colorectal investigations specifically for screening, than those with NFHC. In fully adjusted logistic regression models, FHC was significantly associated with a recent history of faecal occult blood tests (FOBTs), colonoscopies, and colorectal investigations (FOBT or colonoscopy) specifically for screening as part of the national organized screening programme.
Our results indicate that those with a FHC have different patterns of health-related behaviour than those with NFHC.
尽管癌症家族史（FHC）可以改变生活方式和对参与癌症筛查计划的态度，但关于这种关系的研究结果喜忧参半，且因人群而异。本研究的目的是比较有 FHC 和无 FHC（NFHC）人群的社会人口学特征、胃肠道（GI）检查和幽门螺杆菌根除史以及可改变的癌症危险因素，并探讨 FHC 与 GI 检查史之间的关联。
对拉脱维亚“幽门螺杆菌根除和胃蛋白酶原检测预防胃癌死亡率（GISTAR 研究）”的试点研究中的 3455 份问卷进行了分析。我们比较了报告有 FHC 和 NFHC 的参与者之间的社会人口学特征和 GI 检查史。针对 FHC 和每种 GI 检查，建立了调整社会人口学特征和可改变的癌症危险因素的二元逻辑回归模型。
与 NFHC 相比，有 FHC 的参与者更有可能是女性，具有更高的教育程度，且更不可能有不良习惯（吸烟、饮酒）。有 FHC 的参与者更有可能报告最近专门用于筛查的结直肠检查，而 NFHC 则不然。在完全调整的逻辑回归模型中，FHC 与最近的粪便潜血试验（FOBT）、结肠镜检查以及专门作为国家组织筛查计划一部分的结直肠检查（FOBT 或结肠镜检查）呈显著相关。
我们的研究结果表明，有 FHC 的人与 NFHC 的人在健康相关行为方面存在差异。
