Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Urology, University of Tsukuba, Ibaraki, Japan.
Neurourol Urodyn. 2021 Jan;40(1):326-333. doi: 10.1002/nau.24562. Epub 2020 Oct 29.
To evaluate the relationship between nocturia and medical history of nocturnal enuresis: two conditions where diurnal urination rhythm is disturbed.
The Nagahama study is a longitudinal population-based health survey involving people aged 30-75 years in Nagahama city, Japan. Our analysis included 5,402 participants who completed enuresis and International Prostate Symptom Score questionnaires. Associations between nocturnal enuresis and nocturia were evaluated cross-sectionally and longitudinally with three models: (1) univariate analysis; (2) adjusted for basic characteristics (e.g., age, sex, body mass index, activity, alcohol, and smoking); and (3) adjusted for basic and clinical variables (e.g., hyperglycemia, hyperlipidemia, hypertension, renal insufficiency, insomnia, obstructive sleep apnea, and mental health).
In total, 1,613 participants (29.9%) had a medical history of enuresis. The mean night-time frequency was 0.73 at baseline and 0.85 at the 5-year follow-up. The cross-sectional analysis showed participants with a medical history of enuresis had night-time frequency more often than those without this history (0.84 vs. 0.68, p < .0001). Significant differences were observed in Models 2 (p < .0001) and 3 (p < .0001). The longitudinal analysis showed nocturia progression was significantly related to a history of enuresis, with odds ratios of 1.32 (p < .0001) in Model 1, 1.21 (p < .01) in Model 2, and 1.22 (p < .01) in Model 3.
Medical history of enuresis during school age was significantly related to nocturia in adulthood in the cross-sectional analysis, and to progression to nocturia in the longitudinal analysis. These two conditions may possess a common causative association.
评估夜尿症与遗尿病史之间的关系：这两种情况均存在日间排尿节律紊乱。
长滨研究是一项基于人群的纵向健康调查，涉及日本长滨市 30-75 岁的人群。我们的分析包括完成遗尿和国际前列腺症状评分问卷的 5402 名参与者。使用三种模型评估遗尿和夜尿症之间的横断面和纵向关联：（1）单变量分析；（2）调整基本特征（如年龄、性别、体重指数、活动、酒精和吸烟）；（3）调整基本和临床变量（如高血糖、高血脂、高血压、肾功能不全、失眠、阻塞性睡眠呼吸暂停和心理健康）。
共有 1613 名参与者（29.9%）有遗尿病史。基线时夜间频率为 0.73，5 年随访时为 0.85。横断面分析显示，有遗尿病史的参与者夜间频率高于无遗尿病史的参与者（0.84 比 0.68，p<0.0001）。在模型 2（p<0.0001）和模型 3（p<0.0001）中也观察到了显著差异。纵向分析显示，夜尿症进展与遗尿病史显著相关，模型 1 中比值比为 1.32（p<0.0001），模型 2 中为 1.21（p<0.01），模型 3 中为 1.22（p<0.01）。
在校期间有遗尿病史与成年后夜尿症在横断面分析中显著相关，与夜尿症进展在纵向分析中显著相关。这两种情况可能具有共同的因果关联。
