Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.
Nanoscale. 2020 Nov 12;12(43):22129-22139. doi: 10.1039/d0nr05993e.
Herein, we present a new design on the Single Needle Electrochemical Therapy (SNEChT) method by introducing some major improvements, including a nanoporous platinum electrode, tunable in situ anode size that depends on the width and location of the tumor, and the capability of measuring the efficacy of therapy based in intra-therapeutic impedance recording by the same EChT needle. It could have significant implications in optimizing EChT operative conditions. The nanoporous Pt electrode increased the interactive surface with a tumor, and produced a higher amount of current with lower stimulating DC voltage. The tunable anode size prevents the over-acidification of treated or non-desired lesions. Hence, this feature reduced the over distribution of tissue. Monitoring the impedance during the therapy clearly informs us about the local destruction of the tumor in each location. Thus, we can be informed about the threshold of tissue acidosis with the lowest electrical stimulation. The insertion of one needle with a tunable anode length for both precise therapy and impedance-based intra-therapeutic monitoring will shed new light on the applications of EChT.
在此，我们提出了一种新的单针电化学疗法（SNEChT）设计，通过引入一些重大改进，包括纳米多孔铂电极、可根据肿瘤的宽度和位置调节的原位可调阳极尺寸，以及基于同一 EChT 针的治疗内阻抗记录来测量治疗效果的能力。它可以在优化 EChT 手术条件方面产生重大影响。纳米多孔 Pt 电极增加了与肿瘤的相互作用表面，并产生了更高的电流，同时降低了刺激的直流电压。可调阳极尺寸可防止治疗或非所需病变过度酸化。因此，该特性减少了组织的过度分布。在治疗过程中监测阻抗可以清楚地了解每个位置肿瘤的局部破坏情况。因此，我们可以了解到最低电刺激下组织酸中毒的阈值。插入一根带有可调阳极长度的针，用于精确治疗和基于阻抗的治疗内监测，这将为 EChT 的应用带来新的曙光。
