Miripour Zohreh Sadat, Ghahremani Alireza, Karimi Koosha, Jahanbakhsh Fahimeh, Abbasvandi Fereshteh, Hoseinpour Parisa, Parniani Mohammad, Abdolahad Mohammad
Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.
UT&TUMS Cancer Electronics Research Center, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.
Med Oncol. 2023 Mar 16;40(4):117. doi: 10.1007/s12032-023-01979-x.
There is a critical need for re-evaluation of electrochemical therapy (EChT) approaches of solid tumors to address the challenges of the currently used method: incomplete pathological response. The coexistence of anode and cathode in the tumor region resulted in acid-alkaline mixation (buffered pH) when the electrodes are so near each other (d < 1 cm), and in the non-affected lesions when the electrodes are far from each other (d > 1 cm), both have resulted in intact tumoral lesions in EChT field. Here, we presented a designation model study of EChT with an external anode out of the tumor and filled the tumor with dense distribution of cathode electrodes to completely destroy the tumoral lesions without any remaining vital tumoral residues. Anode was located in a biological ionic gel chamber (located on top of the skin) which mediates the ionic interface between the external anode and intratumoral cathode. Our newly reported method can solve the lack of a comprehensive therapeutic guideline for any solid tumors. A remarkable increase in the efficiency of EChT without any over-treating was achieved by alkaline therapy of the tumor (without any limitation in locating cathodic needles all over the tumor) and an external acidic region on top of the skin in a cylindrical gel chamber. We found that the destructive volumes and treating ability of mice tumors by this newly represented method were more significant than the conventional EChT method in fewer therapy sessions and no damage to the skin (both anode and cathode electrodes inside the tumor) (P < 0.05). Results of this study applied to mouse model tumors shed new light on returning attraction to EChT as a valuable complementary method for treating different types of solid breast tumors.
迫切需要重新评估实体肿瘤的电化学疗法（EChT），以应对当前使用方法所面临的挑战：病理反应不完全。当电极彼此靠近（d < 1 cm）时，肿瘤区域中阳极和阴极的共存导致酸碱混合（缓冲pH），而当电极彼此远离（d > 1 cm）时，在未受影响的病变中，这两种情况都导致了EChT区域内肿瘤病变的完整。在此，我们提出了一种EChT的设计模型研究，将外部阳极置于肿瘤外，并在肿瘤内密集分布阴极电极，以完全破坏肿瘤病变，不留下任何存活的肿瘤残余物。阳极位于生物离子凝胶室（位于皮肤顶部）中，该凝胶室介导外部阳极与肿瘤内阴极之间的离子界面。我们新报道的方法可以解决任何实体肿瘤缺乏全面治疗指南的问题。通过对肿瘤进行碱性治疗（在肿瘤内放置阴极针不受任何限制）以及在圆柱形凝胶室中皮肤顶部设置外部酸性区域，在不进行任何过度治疗的情况下，EChT的效率显著提高。我们发现，通过这种新提出的方法，小鼠肿瘤的破坏体积和治疗能力在较少的治疗次数中比传统EChT方法更显著，并且对皮肤无损伤（肿瘤内的阳极和阴极电极均如此）（P < 0.05）。这项针对小鼠模型肿瘤的研究结果为将EChT作为治疗不同类型实体乳腺肿瘤的有价值辅助方法重新吸引人们的关注提供了新的思路。
