磷酸化分析物：在全球磷酸化蛋白质组学数据集的底物激酶网络的交互查询。
Phosphomatics: interactive interrogation of substrate-kinase networks in global phosphoproteomics datasets.
机构信息
Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
Nuritas Limited, Dublin D02 RY95, Ireland.
出版信息
Bioinformatics. 2021 Jul 12;37(11):1635-1636. doi: 10.1093/bioinformatics/btaa916.
MOTIVATION
Mass spectrometry-based phosphoproteomics can routinely identify and quantify thousands of phosphorylated peptides from a single experiment. However interrogating possible upstream kinases and identifying key literature for phosphorylation sites is laborious and time-consuming.
RESULTS
Here, we present Phosphomatics-a publicly available web resource for interrogating phosphoproteomics data. Phosphomatics allows researchers to upload phosphoproteomics data and interrogate possible relationships from a substrate-, kinase- or pathway-centric viewpoint.
AVAILABILITY AND IMPLEMENTATION
Phosphomatics is freely available via the internet at: https://phosphomatics.com.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
基于质谱的磷酸化蛋白质组学通常可以从单个实验中鉴定和定量数千种磷酸化肽。然而，查询可能的上游激酶并识别磷酸化位点的关键文献是繁琐和耗时的。
结果
在这里，我们介绍了 Phosphomatics，这是一个用于查询磷酸化蛋白质组学数据的公共可用的网络资源。Phosphomatics 允许研究人员上传磷酸化蛋白质组学数据，并从底物、激酶或途径为中心的角度来查询可能的关系。
可用性和实现
Phosphomatics 可通过互联网免费获得：https://phosphomatics.com。
补充信息
补充数据可在 Bioinformatics 在线获得。
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