Silver-Catalyzed Cascade Cyclization/1,6-Conjugate Addition of Homopropargyl Sulfonamides to -Quinone Methides: An Approach to Diverse 3-Diarylmethine Substituted Dihydropyrroles.

A silver-catalyzed cycloisomerization/1,6-conjugate addition of homopropargyl sulfonamides to -quinone methides to access diverse diarylmethine substituted dihydropyrroles has been disclosed. The reaction pathway involves an intramolecular cascade cyclization of homopropargyl sulfonamides to generate a highly reactive dihydropyrrole intermediate in situ followed by conjugate addition with -quinone methides. This method provides an efficient and scalable route for the synthesis of 3-diarylmethine substituted dihydropyrroles, in one pot.