Laboratory of Physiology of the Visceral Systems, Institute of the Experimental Medicine, St. Petersburg, Russia.
Bull Exp Biol Med. 2020 Oct;169(6):751-754. doi: 10.1007/s10517-020-04971-x. Epub 2020 Oct 29.
Changes in pulmonary microhemodynamics during modelling of pulmonary thromboembolism against the background of nebivolol and mirabegron pretreatment were studied in isolated perfused rabbit lungs. In both cases, the pulmonary artery pressure and precapillary and pulmonary vascular resistance increased to a greater extent than in control animals, but the increase in capillary hydrostatic pressure was less pronounced. The postcapillary resistance did not change in pulmonary embolism against the background of nebivolol administration and increased in case of mirabegron pretreatment; capillary filtration coefficient after nebivolol pretreatment increased less markedly than after mirabegron administration. The increase in capillary filtration coefficient after activation of β-adrenoceptors with the specified drugs depended on the ratio of constriction of pulmonary veins, capillary hydrostatic pressure, and endothelial permeability.
在离体灌注兔肺模型中，研究了在预先给予比索洛尔和米拉贝隆的情况下，肺血栓栓塞症时肺微血管血液动力学的变化。在这两种情况下，肺动脉压和小动脉及肺血管阻力的增加程度均大于对照组，但毛细血管静水压力的增加程度较轻。比索洛尔预处理时，肺栓塞时后毛细血管阻力无变化，而米拉贝隆预处理时则增加；比索洛尔预处理后毛细血管滤过系数的增加幅度小于米拉贝隆给药后。用特定药物激活β肾上腺素受体后毛细血管滤过系数的增加取决于肺静脉收缩、毛细血管静水压力和内皮通透性的比值。
