Department of Orthopedic Surgery, The First Affiliated Hospital of China Medical University, Liaoning, China.
Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Ecotoxicol Environ Saf. 2021 Jan 15;208:111518. doi: 10.1016/j.ecoenv.2020.111518. Epub 2020 Oct 22.
To investigate the associations between short-term exposure to fine particular matter (PM) and ischemic stroke (IS) in Yancheng, China, from 2017 to 2019.
We designed a time-series study based on generalized additive models to explore the association of PM and IS admitted in two major hospitals in Yancheng. We built different lag patterns and conducted stratification analyses by age, gender, and season. Moreover, we examined the robustness of the associations adopting two-pollutant models and fitted the concentration-response curves.
We observed positive and significant associations at lag 0 day. Every 10 μg/m increase in PM (lag0) was associated with 1.06% (95% CI: 0.21%-1.91%) increases in hospitalizations for IS. The association remained stable and statistically significant to the adjustment of carbon monoxide and ozone. We observed that the associations were stronger in females and during cold seasons. The overall concentration-response relationship curve was linear positive and increased slowly but rose sharply at higher concentrations in the cold season.
Our study added to the evidence that short-term exposure to PM may induce IS, and the government should take action to address the air pollution issues and protect susceptible populations.
探讨 2017 年至 2019 年期间中国盐城短期暴露于细颗粒物（PM）与缺血性脑卒中（IS）的关系。
我们设计了一项基于广义加性模型的时间序列研究，以探讨 PM 与盐城两家主要医院收治的 IS 之间的关系。我们构建了不同的滞后模式，并按年龄、性别和季节进行了分层分析。此外，我们采用双污染物模型检验了关联的稳健性，并拟合了浓度-反应曲线。
我们在滞后 0 天观察到阳性且显著的关联。PM（lag0）每增加 10μg/m，IS 住院率增加 1.06%（95%CI：0.21%-1.91%）。该关联在调整一氧化碳和臭氧后仍然稳定且具有统计学意义。我们发现，该关联在女性和寒冷季节更强。在整个浓度-反应关系曲线上，呈线性正相关，在寒冷季节浓度较高时缓慢增加，但急剧上升。
本研究进一步证实了短期暴露于 PM 可能导致 IS，政府应采取行动解决空气污染问题，保护易感人群。
