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司库奇尤单抗在伴有结核性葡萄膜炎的强直性脊柱炎中的作用。

Role of secukinumab in ankylosing spondylitis with tubercular uveitis.

作者信息

Mahendradas Padmamalini, Jain Vikramraj K, Thomas Sherina, Kawali Ankush, Sanjay Srinivasan, Shetty Bhujang K

机构信息

Department of Uveitis and Ocular Immunology Services, Narayana Nethralaya, Bangalore, Karnataka, India.

Department of Clinical Immunology and Rheumatology, Bhagwan Mahavir Jain Hospital, Bangalore, Karnataka, India.

出版信息

Indian J Ophthalmol. 2020 Nov;68(11):2569-2572. doi: 10.4103/ijo.IJO_1081_20.

Abstract

We present the case of a 32-year-old Indian male one-eyed individual with a history of unilateral panuveitis with HLA B 27 positive spondyloarthropathy on systemic immunosuppressant (Adalimumab). He developed recurrent inflammation in the same eye in a span of 2 years, later complicated with retinal vasculitis. On evaluation, he was diagnosed with tubercular uveitis and started on antitubercular treatment along with systemic steroids. Inview of Increased IOP due to steroid response, Inj. Secukinumab ( IL 17 A inhibitor) was started and significant improvement was noted.

摘要

我们报告了一例32岁的印度男性独眼患者的病例,该患者有单侧全葡萄膜炎病史,患有HLA B 27阳性脊柱关节病,正在接受全身性免疫抑制剂(阿达木单抗)治疗。在2年的时间里,他同一只眼睛反复出现炎症,后来并发视网膜血管炎。经评估,他被诊断为结核性葡萄膜炎,并开始接受抗结核治疗及全身性类固醇治疗。鉴于类固醇反应导致眼压升高,开始使用司库奇尤单抗注射液(IL 17 A抑制剂),并观察到显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d9/7774187/cea9492f10bd/IJO-68-2569-g001.jpg

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