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胃食管反流病与抑郁症之间的关联:一项系统评价与荟萃分析方案

Association between gastroesophageal reflux disease and depression disorder: A protocol for systematic review and meta-analysis.

作者信息

Liu Yu, Zhou Panpan, Zhang Shixiong, Wu Huiqing, Yang Zeqi, Xu Miaochan, Liu Shaowei, Wang Yangang

机构信息

School of Pharmacy, Hebei University of Chinese Medicine.

Department of Gastroenterology, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang, Hebei, P.R. China.

出版信息

Medicine (Baltimore). 2020 Oct 23;99(43):e22696. doi: 10.1097/MD.0000000000022696.

Abstract

BACKGROUND

This study will systematically synthesize the evidence on the potential association between gastroesophageal reflux disease (GERD) and depression disorder (DD).

METHODS

We will search the following electronic bibliographic databases: PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, the Chinese Bio Medical Literature Database, China National Knowledge Infrastructure (CNKI), the China Science and Technology Journal database (VIP) and Wanfang Data. In addition, ongoing trials will be retrieved from the WHO ICTRP Search Portal, the Chinese Clinical Trial Register and The Clinical Trials Register. Articles related to gastroesophageal reflux disease and depression will be searched. And language and time will be unlimited.

RESULTS

The study will afford additional insight into the investigation the association between GERD and DD.

CONCLUSIONS

The results of this study will provide helpful evidence to explore the association between GERD and DD.

REGISTRATION NUMBER

INPLASY202090026.

摘要

背景

本研究将系统地综合关于胃食管反流病(GERD)与抑郁症(DD)之间潜在关联的证据。

方法

我们将检索以下电子文献数据库:PubMed/MEDLINE、Embase、Cochrane图书馆、科学网、中国生物医学文献数据库、中国知网(CNKI)、中国科技期刊数据库(维普)和万方数据。此外,还将从世界卫生组织国际临床试验注册平台搜索门户、中国临床试验注册中心和临床试验注册中心检索正在进行的试验。将搜索与胃食管反流病和抑郁症相关的文章。语言和时间不限。

结果

该研究将为深入调查GERD与DD之间的关联提供更多见解。

结论

本研究结果将为探索GERD与DD之间的关联提供有益证据。

注册号

INPLASY202090026。

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1
The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression.微生物群-肠-免疫-神经胶质(MGIG)轴与重度抑郁症。
Mol Neurobiol. 2020 Oct;57(10):4269-4295. doi: 10.1007/s12035-020-01961-y. Epub 2020 Jul 22.
4
Therapeutic Potential of for Depressive Disorder.用于治疗抑郁症的潜力。
Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163.

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