Li Lekun, Liu Yujie, Ren Xiaofeng, Qu Kai, Liu Xiaona
Department of Spinal Surgery.
Department of Nursing, Liaocheng People's Hospital, Liaocheng, Shandong Province.
Medicine (Baltimore). 2020 Oct 23;99(43):e22711. doi: 10.1097/MD.0000000000022711.
Advanced nursing care (ANC) has been reported to effectively relieve bone cancer pain, prevent psychological disorders and improve the quality of life (QoL) in patients with primary bone cancers (PBC) during the treatment. However, the exact effect of ANC remains controversial. This systematic review will aimed to assess the effectiveness of ANC on bone cancer pain, psychological disorders and QoL in patients with PBC.
Eligible randomized controlled trials (RCTs) and high-quality prospective cohort studies were searched from Excerpt Medica Database (Embase), PubMed, Google Scholar, Medline, Cochrane Library, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), Chinese Bio Medical Database (CBM), China Scientific Journal Database (CSJD), and Wanfang Database. Papers in English or Chinese published from January 2000 to July 2020 will be included without any restrictions. The clinical outcomes including bone cancer pain, psychological disorders, QoL, and adverse events of ANC in patients with PBC were systematically evaluated.Two reviewers will separately carry out study selection and data extraction. Stata 14.0 and Review Manager 5.3 were used for data analysis. Methodological quality for each eligible clinical trial will be assessed by using Cochrane risk of bias tool. Subgroup and meta-regression analysis will be carried out depending on the availability of sufficient data.
This study will comprehensively summarize all potential evidence to systematically investigate the effects and safety of ANC on bone cancer pain, psychological disorders and QoL in patients with PBC.
The findings of this study will help to determine whether ANC is effective or not on bone cancer pain, psychological disorders and QoL in patients with PBC.
INPLASY202090037.
据报道，高级护理（ANC）可有效缓解原发性骨癌（PBC）患者在治疗期间的骨癌疼痛，预防心理障碍并提高生活质量（QoL）。然而，ANC的确切效果仍存在争议。本系统评价旨在评估ANC对PBC患者骨癌疼痛、心理障碍和生活质量的有效性。
从医学文摘数据库（Embase）、PubMed、谷歌学术、Medline、Cochrane图书馆、科学引文索引（WOS）、中国知网（CNKI）、中国生物医学数据库（CBM）、中国科学期刊数据库（CSJD）和万方数据库中检索符合条件的随机对照试验（RCT）和高质量前瞻性队列研究。纳入2000年1月至2020年7月发表的英文或中文论文，无任何限制。系统评价PBC患者中ANC的临床结局，包括骨癌疼痛、心理障碍、生活质量和不良事件。两名评价者将分别进行研究筛选和数据提取。使用Stata 14.0和Review Manager 5.3进行数据分析。使用Cochrane偏倚风险工具评估每个符合条件的临床试验的方法学质量。将根据是否有足够的数据进行亚组分析和meta回归分析。
本研究将全面总结所有潜在证据，以系统地研究ANC对PBC患者骨癌疼痛、心理障碍和生活质量的影响及安全性。
本研究结果将有助于确定ANC对PBC患者的骨癌疼痛、心理障碍和生活质量是否有效。
INPLASY注册号：INPLASY202090037。
