Zhang Lei, Zhang Xuan, Cui Zhaokun, Zhou Lijuan, Qu Kai, Wang Nannan
Department of Oncology, The People's Hospital of Taizhou, Taizhou, Jiangsu Province.
Digestive Endoscopy Center, Liaocheng People's Hospital.
Medicine (Baltimore). 2020 Aug 28;99(35):e21855. doi: 10.1097/MD.0000000000021855.
High quality nursing care (HQNC) has been reported to effectively prevent psychological disorders and improve the quality of life (QoL) in patients with hepatocellular carcinoma (HCC) during the treatment. However, the exact effect of HQNC remains controversial. This systematic review will be aimed to assess the effectiveness of HQNC on psychological disorders and QoL in patients with HCC.
Eligible prospective controlled clinical trials were searched from Google Scholar, Medline, Excerpt Medica Database (Embase), PubMed, Web of Science (WOS), Cochrane Library, China Scientific Journal Database (CSJD), China National Knowledge Infrastructure (CNKI), Chinese BioMedical Database (CBM) and Wanfang Database. Papers in English or Chinese published from January 2000 to July 2020 will be included without any restrictions. The clinical outcomes including psychological outcomes, QoL, and adverse events of HQNC in patients with HCC were systematically evaluated.Study selection and data extraction will be performed independently by two reviewers. Stata 14.0 and Review Manager 5.3 were used for data analysis. Methodological quality for each eligible study will be assessed by using Cochrane risk of bias tool. Subgroup and meta-regression analysis will be carried out depending on the availability of sufficient data.
The results of this systematic review will be published in a peer-reviewed journal.
The results of this study may provide helpful evidence of HQNC on psychological effects and QoL in patients with HCC.
INPLASY202070096.
据报道，高质量护理（HQNC）可有效预防肝细胞癌（HCC）患者在治疗期间出现心理障碍并提高生活质量（QoL）。然而，HQNC的确切效果仍存在争议。本系统评价旨在评估HQNC对HCC患者心理障碍和生活质量的有效性。
从谷歌学术、医学索引数据库（Medline）、医学文摘数据库（Embase）、PubMed、科学引文索引（Web of Science，WOS）、考克兰图书馆、中国科学期刊数据库（CSJD）、中国知网（CNKI）、中国生物医学文献数据库（CBM）和万方数据库中检索符合条件的前瞻性对照临床试验。纳入2000年1月至2020年7月发表的英文或中文论文，无任何限制。系统评价HQNC在HCC患者中的临床结局，包括心理结局、生活质量和不良事件。研究选择和数据提取将由两名评价员独立进行。使用Stata 14.0和RevMan 5.3进行数据分析。使用Cochrane偏倚风险工具评估每项符合条件研究的方法学质量。根据是否有足够数据进行亚组分析和Meta回归分析。
本系统评价的结果将发表在同行评审期刊上。
本研究结果可能为HQNC对HCC患者心理影响和生活质量提供有用证据。
INPLASY注册号：INPLASY202070096。
