肺癌患者的生存与、、的杂合性缺失状态有关。

Survival of Lung Cancer Patients Dependent on the LOH Status for , , and .

机构信息

Dept. of Pathology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.

Minneapolis VA Medical Center, Minneapolis, MN 55417, USA.

出版信息

Int J Mol Sci. 2020 Oct 27;21(21):7971. doi: 10.3390/ijms21217971.

DOI:10.3390/ijms21217971

PMID:33120969

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7662351/

Abstract

Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of , , and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for h was found in 26 of 70 cases (37.1%), that of the locus was found in 33 of 70 (47.1%), and that of the locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for h was associated with favorable prognosis while that of predicted worse prognosis. The survival was much shorter for -loss than -loss, emphasizing the importance of in human NSCLC. The adverse effect of LOH on NSCLC patients' survival was neutralized by simultaneous loss of the h locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability.

摘要

肺癌是世界上癌症死亡的主要原因，比其他任何癌种导致的实体瘤死亡都多。在肺癌中，、和 p53 缺失的预后价值尚不清楚。我们对来自明尼苏达大学退伍军人事务医院和维克森林大学医院的非小细胞肺癌 (NSCLC) 患者进行了生存分析。在明尼苏达大学的样本中，发现 70 例中的 26 例（37.1%）存在 h 的杂合性丢失 (LOH)，33 例（47.1%）存在位点的 LOH，43 例（61.4%）存在位点的 LOH。h 的 LOH 与良好的预后相关，而的 LOH 则预示着更差的预后。与 -loss 相比，-loss 的生存时间更短，这强调了在人 NSCLC 中的重要性。在 NSCLC 和乳腺癌中同时缺失 h 位点可中和 LOH 对 NSCLC 患者生存的不良影响，提示可能对具有转移能力的上皮癌进行治疗。