Department of Chemistry, University of North Carolina Charlotte, Charlotte, NC 28223, USA.
Nanoscale Science Program, University of North Carolina Charlotte, Charlotte, NC 28223, USA.
Molecules. 2020 Oct 27;25(21):4965. doi: 10.3390/molecules25214965.
Polyhedral oligomeric silsesquioxane (POSS) is a promising scaffold to be used as delivery system. POSS can modify the properties of photosensitizers to enhance their efficacy toward photodynamic therapy (PDT). In this work, we designed, synthesized and characterized five different POSS porphyrin () derivatives containing hydrophobic (-) and hydrophilic ( and ) functional groups. In general, all the POSSPs showed a better singlet oxygen quantum yield than the parent porphyrins due to the steric hindrance from the POSS unique structure. and containing isobutyl groups showed better PDT performance in cancer cells at lower concentrations than and . However; at higher concentrations, the containing hydrophilic groups has an enhanced PDT efficiency as compared with the parent porphyrin. We envision that the chemical tunability of POSSs can be used as a promising option to improve the delivery and performance of photosensitizers.
多面体低聚倍半硅氧烷（POSS）是一种很有前途的支架，可用作递药系统。POSS 可以修饰光敏剂的性质，以提高其光动力疗法（PDT）的疗效。在这项工作中，我们设计、合成和表征了五种不同的 POSS 卟啉（）衍生物，它们含有疏水（-）和亲水（和）官能团。一般来说，由于 POSS 独特结构的空间位阻，所有的 POSSPs 都比母体卟啉具有更好的单线态氧量子产率。含异丁基的和在较低浓度下比和在癌细胞中表现出更好的 PDT 性能。然而；在较高浓度下，含亲水基团的比母体卟啉具有更高的 PDT 效率。我们设想 POSS 的化学可调性可用作改善递药和光敏剂性能的有前途的选择。
