调节铱（III）光敏剂的细胞器特异性和细胞毒性，以增强光热治疗应用。
Tuning the organelle specificity and cytotoxicity of iridium(III) photosensitisers for enhanced phototheranostic applications.
机构信息
Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China.
State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China.
出版信息
Chem Commun (Camb). 2021 Nov 11;57(90):12008-12011. doi: 10.1039/d1cc04982h.
PMID:34709253
Abstract
Luminescent cyclometallated iridium(III) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.
摘要
具有多面体低聚倍半硅氧烷（POSS）单元的发光金属铱（III）配合物被设计为高效的治疗诊断试剂，具有可调节的细胞器靶向特性、最小的暗毒性和在缺氧条件下仍具有显著的光毒性。
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