• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

调节铱（III）光敏剂的细胞器特异性和细胞毒性，以增强光热治疗应用。

Tuning the organelle specificity and cytotoxicity of iridium(III) photosensitisers for enhanced phototheranostic applications.

机构信息

Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China.

State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China.

出版信息

Chem Commun (Camb). 2021 Nov 11;57(90):12008-12011. doi: 10.1039/d1cc04982h.

DOI:10.1039/d1cc04982h
PMID:34709253
Abstract

Luminescent cyclometallated iridium(III) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.

摘要

具有多面体低聚倍半硅氧烷（POSS）单元的发光金属铱（III）配合物被设计为高效的治疗诊断试剂，具有可调节的细胞器靶向特性、最小的暗毒性和在缺氧条件下仍具有显著的光毒性。

相似文献

1
Tuning the organelle specificity and cytotoxicity of iridium(III) photosensitisers for enhanced phototheranostic applications.调节铱（III）光敏剂的细胞器特异性和细胞毒性，以增强光热治疗应用。
Chem Commun (Camb). 2021 Nov 11;57(90):12008-12011. doi: 10.1039/d1cc04982h.
2
A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia.一种靶向线粒体的光动力试剂，在缺氧条件下显示出更好的光动力治疗效果。
Angew Chem Int Ed Engl. 2016 Aug 16;55(34):9947-51. doi: 10.1002/anie.201604130. Epub 2016 Jul 6.
3
Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(III) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy.通过选择性修饰 N 端半胱氨酸与金属铱(III) 2-甲酰基苯硼酸配合物来构建光功能肽缀合物，用于细胞器特异性成像、酶活性传感和光动力治疗。
Chem Commun (Camb). 2024 Jun 11;60(48):6186-6189. doi: 10.1039/d4cc01824a.
4
Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer.长波长触发的铱(III)配合物纳米颗粒用于缺氧肿瘤的光动力治疗。
Chem Commun (Camb). 2024 Sep 10;60(73):9938-9941. doi: 10.1039/d4cc03501a.
5
Near-infrared-emitting heteroleptic cationic iridium complexes derived from 2,3-diphenylbenzo[g]quinoxaline as in vitro theranostic photodynamic therapy agents.基于 2,3-二苯基苯并[g]喹喔啉的近红外发射杂环阳离子铱配合物作为体外诊断与治疗的光动力治疗试剂。
Dalton Trans. 2017 Jun 27;46(25):8091-8103. doi: 10.1039/c7dt00913e.
6
Iridium(III) complexes as novel theranostic small molecules for medical diagnostics, precise imaging at a single cell level and targeted anticancer therapy.铱(III)配合物作为新型治疗诊断小分子，可用于医疗诊断、单细胞水平的精确成像和靶向抗癌治疗。
Eur J Med Chem. 2024 Oct 5;276:116648. doi: 10.1016/j.ejmech.2024.116648. Epub 2024 Jul 3.
7
Cyclometalated iridium(iii) complexes for mitochondria-targeted combined chemo-photodynamic therapy.用于线粒体靶向联合化学-光动力治疗的环金属铱(III)配合物。
Dalton Trans. 2020 Mar 17;49(11):3562-3569. doi: 10.1039/d0dt00180e.
8
Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies.具有多面体低聚倍半硅氧烷（POSS）核和铱（III）多吡啶臂的发光分子章鱼：合成、聚集诱导发射、细胞摄取和生物成像研究。
Chemistry. 2019 Aug 9;25(45):10633-10641. doi: 10.1002/chem.201901029. Epub 2019 Jul 9.
9
Trifluoromethyl-Substituted Iridium(III) Complexes: From Photophysics to Photooxidation of a Biological Target.三氟甲基取代的铱（III）配合物：从光物理学到生物靶点的光氧化
Inorg Chem. 2018 Feb 5;57(3):1356-1367. doi: 10.1021/acs.inorgchem.7b02778. Epub 2018 Jan 16.
10
Synthesis of pH-responsive cyclometalated iridium(III) complex and its application in the selective killing of cancerous cells.pH 响应型环金属铱(III)配合物的合成及其在选择性杀伤癌细胞中的应用。
Dalton Trans. 2021 Nov 30;50(46):17338-17345. doi: 10.1039/d1dt03042f.

引用本文的文献

1
An iridium(iii) 3-chloro-6-thio-1,2,4,5-tetrazine complex for cysteine conjugation, bioimaging and photoactivated therapy.一种用于半胱氨酸偶联、生物成像和光活化治疗的铱(III) 3-氯-6-硫代-1,2,4,5-四嗪配合物。
RSC Chem Biol. 2025 May 7. doi: 10.1039/d4cb00316k.
2
Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.闪耀生物系统之光：用于生物成像和生物传感应用的发光过渡金属配合物。
Chem Rev. 2024 Aug 14;124(15):8825-9014. doi: 10.1021/acs.chemrev.3c00629. Epub 2024 Jul 25.
3
Bioorthogonal dissociative rhenium(i) photosensitisers for controlled immunogenic cell death induction.
用于可控诱导免疫原性细胞死亡的生物正交解离铼（I）光敏剂
Chem Sci. 2023 Oct 24;14(46):13508-13517. doi: 10.1039/d3sc04903e. eCollection 2023 Nov 29.
4
Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum.环金属铱配合物-肽杂化物和 CGP37157 通过线粒体与内质网之间的膜融合引发的线粒体钙超载诱导 Paraptosis
Biochemistry. 2022 Apr 19;61(8):639-655. doi: 10.1021/acs.biochem.2c00061. Epub 2022 Apr 1.