Vaccination against contagious caprine pleuropneumonia caused by F38.

Only F38 isolates of mycoplasma cause classical contagious caprine pleuropneumonia (CCPP). Therefore, research has focused on the development of a vaccine that will prevent serious epidemics of the disease in goats. Goats immunized with two doses of a lyophilized preparation of isolated F38 organisms administered 4 weeks apart were completely immune to experimentally induced CCPP. The minimum immunizing dose was 0.15 mg, and this dose was still effective after storage for 14 months at 4 C and 22 C. The duration of immunity induced by a single dose of lyophilized F38 was at least 12 months.