de Oliveira Maísa Soares, Oshiro-Junior João Augusto, Dantas Mariana Morais, da Fonsêca Naara Felipe, Ramos Hilthon Alves, da Silva João Victor Belo, de Medeiros Ana Claudia Dantas
Laboratorio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ciencias Biologicas e da Saude, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58429-500, Campina Grande, Paraiba, Brazil.
Curr Pharm Des. 2021;27(10):1311-1322. doi: 10.2174/1381612826666201029095327.
Bacterial resistance is considered one of the most important public health problems of the century, due to the ability of bacteria to rapidly develop resistance mechanisms, which makes it difficult to treat infections, leading to a high rate of morbidity and mortality. Based on this, several options are being sought as an alternative to currently available treatments, with a particular focus on nanotechnology. Nanomaterials have important potential for use in medical interventions aimed at preventing, diagnosing and treating numerous diseases by directing the delivery of drugs. This review presents data on the use of polymeric nanoparticles having in vitro and in vivo activity against bacteria belonging to the Enterobacteriaceae family.
细菌耐药性被认为是本世纪最重要的公共卫生问题之一，因为细菌能够迅速产生耐药机制，这使得感染难以治疗，导致高发病率和死亡率。基于此，人们正在寻求多种替代目前可用治疗方法的选择，尤其关注纳米技术。纳米材料在旨在通过药物定向递送预防、诊断和治疗多种疾病的医学干预中具有重要的应用潜力。本综述介绍了具有体外和体内抗肠杆菌科细菌活性的聚合物纳米颗粒的使用数据。
