Measurement and Evaluation unit, Science Education Department, University of Nigeria, Nsukka, Nigeria.
Department of Microbiology, Faculty of Biological Sciences, University of Nigeria Nsukka, Nsukka, Nigeria.
World J Microbiol Biotechnol. 2024 Feb 17;40(3):102. doi: 10.1007/s11274-024-03925-z.
Despite significant advancements in diagnostics and treatments over the years, the problem of antimicrobial drug resistance remains a pressing issue in public health. The reduced effectiveness of existing antimicrobial drugs has prompted efforts to seek alternative treatments for microbial pathogens or develop new drug candidates. Interestingly, nanomaterials are currently gaining global attention as a possible next-generation antibiotics. Nanotechnology holds significant importance, particularly when addressing infections caused by multi-drug-resistant organisms. Alternatively, these biomaterials can also be combined with antibiotics and other potent biomaterials, providing excellent synergistic effects. Over the past two decades, nanoparticles have gained significant attention among research communities. Despite the complexity of some of their synthesis strategies and chemistry, unrelenting efforts have been recorded in synthesizing potent and highly effective nanomaterials using different approaches. With the ongoing advancements in nanotechnology, integrating it into medical procedures presents novel approaches for improving the standard of patient healthcare. Although the field of nanotechnology offers promises, much remains to be learned to overcome the several inherent issues limiting their full translation to clinics. Here, we comprehensively discussed nanotechnology-based materials, focusing exclusively on metallic nanomaterials and highlighting the advances in their synthesis, chemistry, and mechanisms of action against bacterial pathogens. Importantly, we delve into the current challenges and prospects associated with the technology.
尽管近年来在诊断和治疗方面取得了重大进展，但抗菌药物耐药性问题仍然是公共卫生领域的一个紧迫问题。现有抗菌药物的疗效降低促使人们努力寻找治疗微生物病原体的替代疗法或开发新的药物候选物。有趣的是，纳米材料目前作为下一代抗生素受到全球关注。纳米技术具有重要意义，特别是在解决多药耐药生物引起的感染时。或者，这些生物材料也可以与抗生素和其他有效生物材料结合使用，产生极好的协同作用。在过去的二十年中，纳米颗粒在研究界引起了广泛关注。尽管一些合成策略和化学性质复杂，但人们一直在不懈努力，通过不同的方法合成有效且高效的纳米材料。随着纳米技术的不断进步，将其整合到医疗程序中为改善患者医疗保健标准提供了新方法。尽管纳米技术领域有很大的发展潜力，但仍有许多问题需要解决，以克服限制其在临床上全面应用的几个固有问题。在这里，我们全面讨论了基于纳米技术的材料，专门关注金属纳米材料，并强调了它们在合成、化学和对抗细菌病原体的作用机制方面的进展。重要的是，我们深入探讨了与该技术相关的当前挑战和前景。
