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2019 年武汉暴发性心肌炎国际研讨会的管理视角。

Management perspectives from the 2019 Wuhan international workshop on fulminant myocarditis.

机构信息

"De Gasperis" Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Health Sciences, University of Milano-Bicocca, Monza, Italy.

"De Gasperis" Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

出版信息

Int J Cardiol. 2021 Feb 1;324:131-138. doi: 10.1016/j.ijcard.2020.10.063. Epub 2020 Oct 26.

Abstract

Fulminant myocarditis (FM) is a form of acute myocardial inflammation leading to rapid-onset hemodynamic instability due to cardiogenic shock or life-threatening arrhythmias. As highlighted by recent registries, FM is associated with high rates of death and heart transplantation, regardless of the underlying histology. Because of a paucity of evidence-based management strategies exists for this disease, an International workshop on FM was held in Wuhan, China, in October 2019, in order to share knowledge on the disease and identify areas of consensus. The present report highlights both agreements and controversies in FM management across the world, focusing the attention on areas of opportunity, FM definition, the use of endomyocardial biopsy and viral identification on heart specimens, treatment algorithms including immunosuppression and the timing of circulatory support escalation. This report incorporates the most recent recommendations from national and international professional societies. Main areas of interest and aims of future prospective observational registries and randomized controlled trials were finally identified and suggested.

摘要

暴发性心肌炎(FM)是一种急性心肌炎症,可因心源性休克或威胁生命的心律失常而迅速出现血流动力学不稳定。最近的注册研究表明,FM 与高死亡率和心脏移植率相关,而与潜在的组织学无关。由于这种疾病缺乏循证管理策略,因此于 2019 年 10 月在中国武汉举行了一次 FM 国际研讨会,以分享有关该疾病的知识并确定共识领域。本报告重点介绍了世界各地 FM 管理方面的共识和争议,关注机会领域、FM 定义、心标本的心肌内膜活检和病毒鉴定、包括免疫抑制在内的治疗算法以及循环支持升级的时机。本报告纳入了来自国家和国际专业协会的最新建议。最后确定并提出了未来前瞻性观察性登记和随机对照试验的主要关注领域和目标。

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