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胫骨造釉细胞瘤的广泛切除及同种异体骨移植治疗。

The treatment of adamantinoma of the tibia by wide resection and allograft bone transplantation.

作者信息

Gebhardt M C, Lord F C, Rosenberg A E, Mankin H J

机构信息

Orthopaedic Oncology Service, Massachusetts General Hospital, Boston 02114.

出版信息

J Bone Joint Surg Am. 1987 Oct;69(8):1177-88.

PMID:3312206
Abstract

Since 1975, nine patients who had adamantinoma of the tibia were treated by the orthopaedic oncology service of the Massachusetts General Hospital and the Children's Hospital, Boston, Massachusetts. All patients were followed for two years or more or until a relapse occurred (mean length of follow-up, 5.3 years). Five of the patients were female and four were male; their ages ranged from fourteen to fifty-six years (mean, 19.1 years). The treatment consisted of staging, wide surgical resection of the tumor, and insertion of a segment of intercalary bone allograft (eight patients) or an osteoarticular segment (one patient). All grafts were fixed with compression plates and screws. All but two of the allografts had united at both the proximal and the distal host-donor junction site by twelve months. None of the patients had a local recurrence but pulmonary metastases developed in one. Four of the patients had complications that affected the final result. The functional results were excellent in five patients, good in one, fair in one, and a failure in two. Seven of the nine patients were asymptomatic and fully functional at the time of writing; only one needed a brace to walk. On the basis of this experience we recommend wide resection and implantation of an intercalary allograft in the treatment of adamantinoma of the tibia.

摘要

自1975年以来,马萨诸塞州综合医院和波士顿儿童医院的骨肿瘤科室对9例患有胫骨造釉细胞瘤的患者进行了治疗。所有患者均随访两年或更长时间,或直至复发(平均随访时间为5.3年)。患者中5例为女性,4例为男性;年龄范围为14至56岁(平均19.1岁)。治疗包括分期、肿瘤广泛手术切除以及植入一段节段间骨移植体(8例患者)或一个骨关节段(1例患者)。所有移植体均用加压钢板和螺钉固定。除2例移植体外,其余所有移植体在12个月时近端和远端宿主-供体结合部位均已愈合。所有患者均无局部复发,但有1例发生了肺转移。4例患者出现了影响最终结果的并发症。5例患者功能结果优秀,1例良好,1例尚可,2例失败。9例患者中有7例在撰写本文时无症状且功能完全正常;只有1例患者行走时需要使用支具。基于这一经验,我们建议对胫骨造釉细胞瘤采用广泛切除并植入节段间同种异体骨移植体的治疗方法。

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