Seppälä M, Rönnberg L, Karonen S L, Kauppila A
Department of Obstetrics and Gynaecology, University Central Hospitals of Helsinki, Finland.
Hum Reprod. 1987 Aug;2(6):453-5. doi: 10.1093/oxfordjournals.humrep.a136569.
The effect of luteal phase supplementation of micronized oral progesterone, 200 mg daily, on the serum levels of endometrial secretory placental protein 14 (PP14)/beta-lactoglobulin homologue was studied in a double blind/cross-over fashion on five infertile women with apparently normal ovulatory cycles. Blood samples were taken on cycle days 10-12, 20-22 and 24-27, and the serum progesterone and PP14 concentrations were measured by specific radioimmunoassays. In each progesterone cycle the serum progesterone levels were higher than in the corresponding placebo cycle. In each case, the serum concentration of endometrial PP14 was also higher during progesterone than placebo treatment, but this was seen in the late luteal phase only. In view of the previous demonstration of endometrial synthesis of PP14 and the immunological identity between PP14 and progestogen-dependent endometrial protein, these results indicate that endometrial protein secretion can be increased by micronized oral progesterone in infertile ovulatory women whose serum progesterone level is within the normal range.
采用双盲/交叉试验方式，对5名排卵周期看似正常的不孕女性研究了黄体期每日补充200毫克微粒化口服孕酮对血清中子宫内膜分泌性胎盘蛋白14（PP14）/β-乳球蛋白同源物水平的影响。在月经周期的第10 - 12天、20 - 22天和24 - 27天采集血样，通过特异性放射免疫分析法测定血清孕酮和PP14浓度。在每个孕酮周期中，血清孕酮水平均高于相应的安慰剂周期。在每种情况下，孕酮治疗期间子宫内膜PP14的血清浓度也高于安慰剂治疗，但仅在黄体晚期出现这种情况。鉴于之前已证明子宫内膜可合成PP14，且PP14与孕激素依赖性子宫内膜蛋白具有免疫同一性，这些结果表明，对于血清孕酮水平在正常范围内的不孕排卵女性，微粒化口服孕酮可增加子宫内膜蛋白分泌。
