Wang Tao, Xia Changsheng, Deng Yanni, Xu Liangbi, Jiang Yanping
Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Digestive Endoscopy Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Front Med (Lausanne). 2025 Aug 12;12:1591462. doi: 10.3389/fmed.2025.1591462. eCollection 2025.
Primary effusion lymphoma (PEL) is a rare B-cell lymphoma with an extremely poor prognosis that is associated with long-term persistent latent infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). However, studies on the correlation between KSHV genotype and PEL development in elderly patients are still lacking. We present the first global case of non-HIV, non-effusive, difficult-to-diagnose PEL with disseminated Kaposi's sarcoma (KS) in an elderly patient of Bouyei nationality, dynamically demonstrating that KSHV and EBV co-infection promote tumorigenesis. Phylogenetic analysis based on the Open Coding Framework (ORF)-K1 gene indicated that five samples from the patient's blood (mtl A), saliva (mtl B), descending colon (mtl C), skin (mtl D), and gastric mucosa (mtl E) may belong to a new subtype, Cnew. KSHV genotypes appear to show a pattern of traceability consistent with the human Y-chromosome DNA haplogroup tree.
原发性渗出性淋巴瘤（PEL）是一种罕见的B细胞淋巴瘤，预后极差，与卡波西肉瘤相关疱疹病毒（KSHV）和爱泼斯坦-巴尔病毒（EBV）的长期持续潜伏感染有关。然而，关于老年患者中KSHV基因型与PEL发生之间相关性的研究仍然缺乏。我们报告了全球首例布依族老年患者发生的非HIV、非渗出性、难以诊断的PEL合并播散性卡波西肉瘤（KS），动态显示KSHV和EBV共同感染促进肿瘤发生。基于开放编码框架（ORF）-K1基因的系统发育分析表明，患者血液（mtl A）、唾液（mtl B）、降结肠（mtl C）、皮肤（mtl D）和胃黏膜（mtl E）的五个样本可能属于一个新的亚型，Cnew。KSHV基因型似乎呈现出与人类Y染色体DNA单倍群树一致的可追溯模式。
