Wang Sumei, Liu Nayan, Tang Qing, Sheng Honghao, Long Shunqin, Wu Wanyin
Department of Oncology, Clinical and Basic Research Team of Traditional Chinese Medicine Prevention and Treatment of Non-Small Cell Lung Cancer, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Front Oncol. 2020 Oct 2;10:553714. doi: 10.3389/fonc.2020.553714. eCollection 2020.
MicroRNA-24 (miR-24) has been widely studied in a variety of human cancers, which plays different roles in specific type of cancers. In the present review, we summarized the recent surveys regarding the role of miR-24 in different human cancers. On the one hand, miR-24 was reported to be down-regulated in some types of cancer, indicating its role as a tumor suppressor. On the other hand, it has shown that miR-24 was up-regulated in some other types of cancer, even in the same type of cancer, suggesting the role of miR-24 being as an oncogene. Firstly, miR-24 was dysregualted in human cancers, which is related to the clinical performance of cancer patients. Thus miR-24 could be used as a potential non-invasive diagnostic marker in human cancers. Secondly, miR-24 was associated with the tumor initiation and progression, being as a promoter or inhibitor. Therefore, miR-24 might be an effective prognostic biomarker in different type of cancers. Lastly, the abnormal expression of miR-24 was involved in the chemo- and radio- therapies of cancer patients, indicating the role of miR-24 being as a predictive biomarker to cancer treatment. Totally, miR-24 contributes to tumorigenesis, tumor progression, and tumor therapy, which closely related to clinic. The present review shows that miR-24 plays a double role in human cancers and provides plenty of evidences to apply miR-24 as a potential novel therapeutic target in treating human cancers.
微小RNA-24（miR-24）已在多种人类癌症中得到广泛研究，它在特定类型的癌症中发挥着不同作用。在本综述中，我们总结了近期关于miR-24在不同人类癌症中作用的研究。一方面，据报道miR-24在某些类型的癌症中表达下调，表明其作为肿瘤抑制因子的作用。另一方面，研究表明miR-24在其他一些类型的癌症中甚至在同一类型癌症的不同情况下表达上调，提示miR-24具有癌基因的作用。首先，miR-24在人类癌症中表达失调，这与癌症患者的临床表现相关。因此，miR-24可作为人类癌症潜在的非侵入性诊断标志物。其次，miR-24与肿瘤的发生和进展相关，可作为促进因子或抑制因子。所以，miR-24可能是不同类型癌症有效的预后生物标志物。最后，miR-24的异常表达参与了癌症患者的化疗和放疗，表明miR-24可作为癌症治疗的预测生物标志物。总体而言，miR-24在肿瘤发生、肿瘤进展和肿瘤治疗中发挥作用，与临床密切相关。本综述表明，miR-24在人类癌症中发挥双重作用，并为将miR-24作为治疗人类癌症潜在的新型治疗靶点提供了大量证据。
