Fujian Provincial Key Laboratory of Transplant Biology, Affiliated Dongfang Hospital, Xiamen University School of Medicine, Fuzhou, Fujian Province, China.
Department of Urology, the 900th Hospital of the Joint Logistics Team, Fujian Medical University, Fuzhou, Fujian Province, China.
Adv Exp Med Biol. 2021;1270:1-29. doi: 10.1007/978-3-030-47189-7_1.
Neuregulins, members of the largest subclass of growth factors of the epidermal growth factor family, mediate a myriad of cellular functions including survival, proliferation, and differentiation in normal tissues through binding to receptor tyrosine kinases of the ErbB family. However, aberrant neuregulin signaling in the tumor microenvironment is increasingly recognized as a key player in initiation and malignant progression of human cancers. In this chapter, we focus on the role of neuregulin signaling in the hallmarks of cancer, including cancer initiation and development, metastasis, as well as therapeutic resistance. Moreover, role of neuregulin signaling in the regulation of tumor microenvironment and targeting of neuregulin signaling in cancer from the therapeutic perspective are also briefly discussed.
神经调节蛋白是表皮生长因子家族中最大亚类的生长因子成员，通过与 ErbB 家族的受体酪氨酸激酶结合，在正常组织中介导包括存活、增殖和分化在内的多种细胞功能。然而，肿瘤微环境中异常的神经调节蛋白信号被越来越多地认为是人类癌症起始和恶性进展的关键因素。在本章中，我们重点讨论神经调节蛋白信号在癌症特征中的作用，包括癌症起始和发展、转移以及治疗耐药性。此外，还简要讨论了神经调节蛋白信号在肿瘤微环境调节中的作用以及从治疗角度靶向神经调节蛋白信号在癌症中的作用。
