促肾上腺皮质激素（1-24）和皮质酮对大鼠脂肪组织中脂蛋白脂肪酶的不同作用。

Disparate effects of ACTH (1-24) and corticosterone on lipoprotein lipase in rat adipose tissue.

作者信息

Baggen M G, Jansen H, Lammers R, Verschoor L, Birkenhäger J C

机构信息

Department of Medicine (III), University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.

出版信息

J Endocrinol. 1987 Sep;114(3):369-72. doi: 10.1677/joe.0.1140369.

DOI:10.1677/joe.0.1140369

PMID:3312463

Abstract

The effects of corticosterone and ACTH(1-24) on lipoprotein lipase (LPL) activity of rat epididymal fat tissue were studied. Hypercorticism induced by s.c. administration of 10 mg corticosterone acetate for 3 days led to a decrease in LPL activity. This decrease could be prevented by treatment of the rats simultaneously with synthetic ACTH(1-24). Adrenalectomy also reduced LPL activity. Corticosterone and ACTH(1-24) treatment had a similar effect on LPL activity in adrenalectomized and intact rats. These results indicate that ACTH(1-24) may affect adipose tissue LPL in the rat by a mechanism in which corticosterone is not involved.

摘要

研究了皮质酮和促肾上腺皮质激素（1 - 24）对大鼠附睾脂肪组织脂蛋白脂肪酶（LPL）活性的影响。通过皮下注射10mg醋酸皮质酮3天诱导的高皮质醇血症导致LPL活性降低。同时用合成促肾上腺皮质激素（1 - 24）治疗大鼠可预防这种降低。肾上腺切除术也降低了LPL活性。皮质酮和促肾上腺皮质激素（1 - 24）处理对去肾上腺大鼠和完整大鼠的LPL活性有类似影响。这些结果表明，促肾上腺皮质激素（1 - 24）可能通过一种不涉及皮质酮的机制影响大鼠脂肪组织中的LPL。